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All KERs

Showing 1351 to 1375 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3237	1553: Increase mutations	885: Increase, Cancer	May 28, 2024	May 28, 2024	None
2023	1713: Increase of autoantibody production	1714: Exacerbation of SLE	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
2022	1712: Increase of Th2 cells producing IL-4	1713: Increase of autoantibody production	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
2799	2073: methemocyanin formation (decrease overall oxygen binding capacity)	2074: Decrease overall oxygen binding capacity (methemocyanin formation)	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2800	2073: methemocyanin formation (decrease overall oxygen binding capacity)	2075: Hemocyanin Bohr effect decrease	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2067	1743: Increase plasma Ang II	1745: Increase,collagen synthesis	Mar 17, 2020	Mar 17, 2020	None
2138	1743: Increase plasma Ang II	68: Increase, Collagen accumulation	May 15, 2020	May 15, 2020	None
2435	1743: Increase plasma Ang II	1852: Increased Ang II type 1 receptor (AT1R)	Jul 13, 2021	Jul 13, 2021	1 AOP 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
398	416: Increase proliferation, Leydig cell	415: Hyperplasia, Leydig cell	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
2748	2054: Increase, impairment of cuticle sclerotization	990: Increase, Incomplete ecdysis	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
2749	2055: Increase, pigmentation	990: Increase, Incomplete ecdysis	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
3741	2410: Increase, 11β-HSD1 activity	2412: Increase, Hepatic intracellular active GC	Feb 24, 2026	Feb 24, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2836	2098: Abnormal Neural Remodeling	341: Impairment, Learning and memory	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2091	1768: Increase, Abnormal osmoregulation	1769: Increase, Body fluid overload	Apr 30, 2020	Apr 30, 2020	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
2181	1768: Increase, Abnormal osmoregulation	1809: Increase, Tissue/organ damage	Nov 2, 2020	Nov 2, 2020	None
3290	1768: Increase, Abnormal osmoregulation	2238: Increased, Blood viscosity	Jul 8, 2024	Dec 3, 2024	None
3722	2408: Increase, Adipose lipolysis	115: Increase, FA influx	Feb 10, 2026	Feb 10, 2026	None
3743	2408: Increase, Adipose lipolysis	465: Increased, FA Influx	Feb 24, 2026	Feb 24, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
2736	2045: Increase, Alcohol dehydrogenase	748: Increased, Estrogen receptor (ER) activity	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
1487	1384: Increase, ammonium (NH4+)	1382: Decrease, surfactant	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
2910	2134: Increase, AR protein expression/abundance	854: Alterations, Cellular proliferation / hyperplasia	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
1473	1376: Increase, angiogenesis	1367: Inhibit, gastric ulcer formation	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
2578	1376: Increase, angiogenesis	1193: N/A, Breast Cancer	Feb 15, 2022	Feb 15, 2022	None
3137	1376: Increase, angiogenesis	1982: Metastasis, Breast Cancer	Mar 5, 2024	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
3308	1376: Increase, angiogenesis	885: Increase, Cancer	Jul 18, 2024	Jul 18, 2024	None

Key Event Relationships (KERs)

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