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All KERs

Showing 1876 to 1900 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3727	1489: Increase, Steatohepatitis	1271: Activation of TGF-β signaling	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1745	1525: Increase, SUR binding	1527: Increase, Cell membrane depolarization	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
1489	1381: Increase, surfactant	1380: Activate, mucosal defense	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
2064	1748: Increase, the risk of acute respiratory failure	1751: Decreased mortality	Mar 17, 2020	Mar 17, 2020	None
2135	1748: Increase, the risk of acute respiratory failure	351: Increased Mortality	May 13, 2020	May 13, 2020	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
741	753: Increase, Thyroid-stimulating hormone (TSH)	739: Increase, Hypertrophy and proliferation (follicular cell)	Nov 29, 2016	Dec 3, 2016	None
888	868: Increase, Tissue Degeneration, Necrosis & Atrophy	869: Increase, Respiratory or Squamous Metaplasia	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
2178	1809: Increase, Tissue/organ damage	1521: Decrease, Growth	Nov 2, 2020	Nov 2, 2020	None
2528	1950: Increase, TNF	1949: Decrease, GLUT4	Nov 18, 2021	Nov 18, 2021	1 AOP 431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
3671	2381: Increase, dopamine receptor gene	746: Increase, Dopaminergic activity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3670	2380: Increase, dopamine transporter gene	746: Increase, Dopaminergic activity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
1354	1271: Activation of TGF-β signaling	1272: Increase, Myofibroblast expansion	Feb 15, 2017	Feb 15, 2017	None
1355	1271: Activation of TGF-β signaling	1273: Expression of Collagen	Feb 15, 2017	Feb 15, 2017	None
1721	1271: Activation of TGF-β signaling	149: Increase, Inflammation	Mar 18, 2018	Mar 18, 2018	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1723	1271: Activation of TGF-β signaling	1457: EMT	Mar 18, 2018	Mar 18, 2018	None
3728	1271: Activation of TGF-β signaling	265: Increase, HSC activation	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
3732	1271: Activation of TGF-β signaling	1606: Activation, Stellate cell	Feb 11, 2026	Feb 11, 2026	None
1663	1471: Increase, Uncoupling of photophosphorylation	1472: Decrease, ATP production	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
795	793: Increase, Urinary bladder calculi	794: Increase, Cytotoxicity (urothelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
3018	2161: Increase, Vascular disrupting effects	2160: Angiogenesis disfunction	Aug 21, 2023	Aug 21, 2023	None
1444	1342: Increase, vascular smooth muscle contraction	1343: Increase, hypertension	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
2738	2046: Increase, Vitellogenin mRNA	2047: Delay, Ovarian maturation	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
336	307: Increase, Vitellogenin synthesis in liver	220: Increase, Plasma vitellogenin concentrations	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
2068	1745: Increase,collagen synthesis	1746: Induction lung fibrosis	Mar 17, 2020	Mar 17, 2020	None
2527	1888: increased atRA concentration	1889: premature meiosis, male germ cells	Nov 10, 2021	Nov 11, 2021	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility

Key Event Relationships (KERs)

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