Key Event Relationships (KERs)

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Showing 2101 to 2125 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1124 1085: Increased, hyperplasia (mammary gland) 1079: Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
1067 1024: Increased, Hypertrophy and proliferation (follicular cell) 1025: Increased, Hyperplasia (follicular cells) Nov 29, 2016 Dec 3, 2016 None
2427 1024: Increased, Hypertrophy and proliferation (follicular cell) 740: Increase, Hyperplasia (follicular cells) Jul 7, 2021 Jul 7, 2021 None
342 376: Increased, Induced Mutations in Critical Genes 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Nov 29, 2016 None
346 376: Increased, Induced Mutations in Critical Genes 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 30, 2016
351 376: Increased, Induced Mutations in Critical Genes 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None
549 376: Increased, Induced Mutations in Critical Genes 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
891 376: Increased, Induced Mutations in Critical Genes 872: Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 3, 2016 None
762 726: Increased, Induction of pyruvate dehydrogenase (PDH) 769: Increase, Oxidative metabolism Nov 29, 2016 Dec 3, 2016
1063 1020: Increased, induction of UDPGT's in liver 1021: Increased, T4/T3 catabolism Nov 29, 2016 Dec 3, 2016 None
1127 1087: Increased, inflammation 1032: Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
1048 1012: Increased, Inhibitory postsynaptic potential 1013: Inhibition, Motor neuron activity Nov 29, 2016 Dec 3, 2016 None
1054 1012: Increased, Inhibitory postsynaptic potential 1014: Induction, Somatic muscle paralysis Nov 29, 2016 Dec 3, 2016
1058 1012: Increased, Inhibitory postsynaptic potential 1019: Induction, pharyngeal muscle paralysis Nov 29, 2016 Dec 3, 2016
547 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts 376: Increased, Induced Mutations in Critical Genes Nov 29, 2016 Nov 29, 2016
362 389: Increased, Intracellular Calcium overload 177: Increase, Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016
892 389: Increased, Intracellular Calcium overload 618: Decreased, Neuronal network function in adult brain Nov 29, 2016 Dec 3, 2016 None
1860 389: Increased, Intracellular Calcium overload 613: Occurrence, Epileptic seizure Feb 13, 2019 Feb 13, 2019 None
1862 389: Increased, Intracellular Calcium overload 55: Cell injury/death Feb 19, 2019 Sep 3, 2023
2140 389: Increased, Intracellular Calcium overload 1788: Status epilepticus May 21, 2020 May 21, 2020 None
2704 389: Increased, Intracellular Calcium overload 2038: Activation, calpain Jul 25, 2022 Jul 25, 2022
2709 389: Increased, Intracellular Calcium overload 1477: OXPHOS, decreased Jul 25, 2022 Jul 25, 2022 None
2710 389: Increased, Intracellular Calcium overload 2017: Endoplasmic reticulum stress Jul 25, 2022 Jul 25, 2022
3042 389: Increased, Intracellular Calcium overload 1816: Mitochondrial dysfunction EMPTY Sep 14, 2023 Sep 14, 2023 None
3091 389: Increased, Intracellular Calcium overload 2078: Loss of drebrin Oct 18, 2023 Apr 4, 2025