Key Event Relationships (KERs)

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Showing 2976 to 3000 of 3129 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2888 18: Activation, AhR 345: N/A, Liver Steatosis Apr 13, 2023 Apr 13, 2023 None
3219 18: Activation, AhR 459: Increase, Liver steatosis May 14, 2024 Jan 30, 2025
3482 18: Activation, AhR 1883: Decreased, ovarian reserve Jan 22, 2025 Jan 22, 2025 None
3533 18: Activation, AhR 2323: Over-expression of PD-L1 in cancer cells May 16, 2025 Feb 25, 2026
750 9: Activation, 5HT2c 294: N/A, Unknown Nov 29, 2016 Dec 3, 2016
1438 1336: Activation, 5-HT2A 1337: Activate, PLC Apr 14, 2017 Apr 14, 2017
1375 1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene 1289: Perturbation of cholesterol Feb 15, 2017 Feb 15, 2017
2986 2163: Activation Sema6A 2164: Activation, Dll4-Notch pathway Aug 20, 2023 Aug 20, 2023
2600 1974: Activation of TP53 1365: Increase, Apoptosis Mar 9, 2022 Mar 9, 2022 None
2601 1974: Activation of TP53 1560: Cell differentiation, altered Mar 17, 2022 Mar 17, 2022 None
2606 1974: Activation of TP53 1979: Premature differentiation Mar 21, 2022 Mar 21, 2022
3105 1974: Activation of TP53 1262: Apoptosis Jan 10, 2024 Jan 10, 2024
319 288: Activation of specific nuclear receptors, Transcriptional change 357: Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
1071 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1029: Increased, adipogenesis Nov 29, 2016 Dec 3, 2016
1072 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1032: Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
1609 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1449: increased adipogenesis Jul 24, 2017 Jul 24, 2017
3711 1028: Activation of specific nuclear receptors, PPAR-gamma activation 202: Inhibition, Nuclear factor kappa B (NF-kB) Jan 16, 2026 Jan 16, 2026
1720 1507: Activation of PPARγ 149: Increase, Inflammation Mar 18, 2018 Mar 18, 2018 None
3697 1507: Activation of PPARγ 202: Inhibition, Nuclear factor kappa B (NF-kB) Dec 3, 2025 Dec 3, 2025 None
2990 2165: Activation of PPAR 2167: Activation of MMP-2 MMP-9 Aug 20, 2023 Aug 20, 2023
2991 2165: Activation of PPAR 2168: Activation of angiopoietin like protein 4 Aug 20, 2023 Aug 20, 2023
2992 2165: Activation of PPAR 2169: Activation of Angiogenic cytokines Aug 20, 2023 Aug 20, 2023
3278 2165: Activation of PPAR 1392: Increase, Oxidative Stress Jul 4, 2024 Jul 4, 2024
1291 1238: Oxidation 1236: Generation of novel epitopes , Antigen presentation Nov 29, 2016 Dec 3, 2016 None
1292 1238: Oxidation 1215: TRPA1 activation, TRPA1 Receptor Nov 29, 2016 Dec 3, 2016 None