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Showing 926 to 950 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2903	1497: Recruitment of inflammatory cells	1633: Increase in inflammation	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1463	1357: Increased, RDX dose	1359: Activate, GABA-A receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1555	1357: Increased, RDX dose	1415: Reduced, GABA-A receptor activation	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
3389	2276: Increased, PCSK9 protein expression	2271: Increased, plasma LDL cholesterol	Nov 13, 2024	Feb 10, 2025	1 AOP 548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
343	377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	None
1076	1033: Increased, proliferation of mesenchymal cells	1035: Increased, Firbrosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1077	1033: Increased, proliferation of mesenchymal cells	1036: Increased, liposarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1078	1033: Increased, proliferation of mesenchymal cells	1037: Increased, hemagiosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1266	1189: Increased, Proliferation (Endothelial cells)	1213: Increased, Angiogenesis	Nov 29, 2016	Dec 20, 2022	1 AOP 200: Estrogen receptor activation leading to breast cancer
1122	1084: Increased, prolactin secretion	1085: Increased, hyperplasia (mammary gland)	Nov 29, 2016	Dec 3, 2016	1 AOP 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1114	1077: Increased, prolactin exposure	1078: Hyperplasia, Mammary gland	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
595	588: Increased, predation	592: Reduced, survival	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
654	588: Increased, predation	636: Decreased, survival	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
1095	1057: Increased, PPAR-alpha activation	1058: Decreased, bile flow	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1096	1057: Increased, PPAR-alpha activation	1059: Increased, cholestasis	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1097	1057: Increased, PPAR-alpha activation	1060: Alteration, lipid metabolism	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
776	775: Increased, Plasma tyrosine	776: Increase, Cytotoxicity (corneal cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
1960	1665: Plasma HCY level	1666: dysfunction of microcirculation	Jul 3, 2019	Jul 3, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1526	1399: Increased, packaged serotonin	1400: Increased, synaptic release	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
3597	2351: Increased, OXPHOS	2352: Increased, MMP	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1213	1161: Increased, oocyte maturation	1163: Increased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
1328	1161: Increased, oocyte maturation	1255: induced spawning	Jan 17, 2017	Jan 17, 2017	1 AOP 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
2633	1990: Increased, Oocyte Atresia	1991: Impaired, Reproduction	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1697	1491: increased, oncotic necrosis	1489: Increase, Steatohepatitis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1295	1191: Increased, Non-genomic signaling	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer

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