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Showing 1276 to 1300 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3490	1115: Increase, ROS	1634: Increase, Oxidative DNA damage	Feb 25, 2025	Feb 25, 2025	3 AOPs 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 330: Excessive reactive oxygen species production leading to mortality (4)
3491	1115: Increase, ROS	1767: Increase, Protein oxidation	Feb 25, 2025	Feb 25, 2025	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
3492	1115: Increase, ROS	1446: Decrease, Coupling of OXPHOS	Feb 25, 2025	Feb 25, 2025	None
3494	1115: Increase, ROS	193: Decreased, Nitric Oxide	Feb 25, 2025	Feb 25, 2025	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
3496	1115: Increase, ROS	177: Increase, Mitochondrial dysfunction	Feb 25, 2025	Feb 25, 2025	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
3505	1115: Increase, ROS	1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation	Mar 6, 2025	Jul 22, 2025	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
3509	1115: Increase, ROS	209: Peptide Oxidation	Apr 3, 2025	Apr 3, 2025	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
3513	1115: Increase, ROS	1594: Oxidation of membrane lipids	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3514	1115: Increase, ROS	1595: Oxidation/denatuation of membrane proteins	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3537	1115: Increase, ROS	2195: Increase, CNS Neural cell death	May 22, 2025	May 22, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
3611	1115: Increase, ROS	1862: Decrease, Photosystem II efficiency	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3614	1115: Increase, ROS	112: Antagonism, Estrogen receptor	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3680	1115: Increase, ROS	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3758	1115: Increase, ROS	1967: Pyroptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
272	246: Increase, RBC congestion in liver	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
2802	2077: behavioral change leading to possible reduced feeding opportunity	1521: Decrease, Growth	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2090	1767: Increase, Protein oxidation	1768: Increase, Abnormal osmoregulation	Apr 30, 2020	Apr 30, 2020	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
2223	1767: Increase, Protein oxidation	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
3361	1767: Increase, Protein oxidation	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3568	1767: Increase, Protein oxidation	1994: Ferroptosis	Aug 13, 2025	Aug 13, 2025	None
3633	1767: Increase, Protein oxidation	1446: Decrease, Coupling of OXPHOS	Sep 8, 2025	Jun 23, 2026	3 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 332: Increase in reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Increase in reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3634	1767: Increase, Protein oxidation	179: Decrease, Fatty acid β-oxidation	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3636	1767: Increase, Protein oxidation	1505: Cell cycle disruption	Sep 8, 2025	Sep 8, 2025	1 AOP 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
3838	1767: Increase, Protein oxidation	1815: Increase, ER stress	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
944	923: Increased goblet cell proliferation	921: Goblet cell hyperplasia	Nov 29, 2016	Aug 27, 2021	None

Key Event Relationships (KERs)

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