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All KERs

Showing 1276 to 1300 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3509	1115: Increase, ROS	209: Peptide Oxidation	Apr 3, 2025	Apr 3, 2025	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
3513	1115: Increase, ROS	1594: Oxidation of membrane lipids	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3514	1115: Increase, ROS	1595: Oxidation/denatuation of membrane proteins	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3537	1115: Increase, ROS	2195: Increase, CNS Neural cell death	May 22, 2025	May 22, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
3611	1115: Increase, ROS	1862: Decrease, Photosystem II efficiency	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3614	1115: Increase, ROS	112: Antagonism, Estrogen receptor	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3680	1115: Increase, ROS	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3758	1115: Increase, ROS	1967: Pyroptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
272	246: Increase, RBC congestion in liver	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
2802	2077: behavioral change leading to possible reduced feeding opportunity	1521: Decrease, Growth	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2090	1767: Increase, Protein oxidation	1768: Increase, Abnormal osmoregulation	Apr 30, 2020	Apr 30, 2020	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
2223	1767: Increase, Protein oxidation	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
3361	1767: Increase, Protein oxidation	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3568	1767: Increase, Protein oxidation	1994: Ferroptosis	Aug 13, 2025	Aug 13, 2025	None
3633	1767: Increase, Protein oxidation	1446: Decrease, Coupling of OXPHOS	Sep 8, 2025	Sep 8, 2025	1 AOP 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death
3634	1767: Increase, Protein oxidation	179: Decrease, Fatty acid β-oxidation	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3636	1767: Increase, Protein oxidation	1505: Cell cycle, disrupted	Sep 8, 2025	Sep 8, 2025	1 AOP 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
944	923: Increased goblet cell proliferation	921: Goblet cell hyperplasia	Nov 29, 2016	Aug 27, 2021	None
2339	1864: Increase, Programmed cell death	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	None
2553	1864: Increase, Programmed cell death	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 388: Deposition of ionising energy leading to population decline via programmed cell death
2835	2097: Increase, Pro-Inflammatory Mediators	2098: Abnormal Neural Remodeling	Jan 25, 2023	Sep 10, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2839	2097: Increase, Pro-Inflammatory Mediators	341: Impairment, Learning and memory	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
774	774: Increase, Preneoplastic foci (hepatocytes)	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Feb 15, 2017	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
1744	1524: Increase, Premature molting	350: Increase, Mortality	May 24, 2018	Feb 17, 2021	5 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
2634	623: Increase, predation	360: Decrease, Population growth rate	Apr 6, 2022	Apr 6, 2022	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline

Key Event Relationships (KERs)

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