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Showing 1451 to 1475 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3156	177: Increase, Mitochondrial dysfunction	835: Occurrence, Ballooning degeneration (hepatocyte)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3157	177: Increase, Mitochondrial dysfunction	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3158	177: Increase, Mitochondrial dysfunction	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Mar 13, 2024	Mar 13, 2024	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
3161	177: Increase, Mitochondrial dysfunction	2144: Impaired insulin signaling	Mar 13, 2024	Mar 13, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3164	177: Increase, Mitochondrial dysfunction	1917: Altered expression of NRF2 pathway-dependent genes	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3165	177: Increase, Mitochondrial dysfunction	202: Inhibition, Nuclear factor kappa B (NF-kB)	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3767	177: Increase, Mitochondrial dysfunction	188: Neuroinflammation	Apr 2, 2026	Apr 2, 2026	1 AOP 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
2183	1811: Increase, Complex III dysfunction	1812: Increase, Cyt c release	Nov 2, 2020	Nov 2, 2020	None
2119	1785: Increase, Mitochondrial ATP synthase antagonism	1477: OXPHOS, decreased	May 8, 2020	May 8, 2020	None
2229	1785: Increase, Mitochondrial ATP synthase antagonism	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
3641	2373: Increase, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
3461	2302: Increase, Malformations	351: Increased Mortality	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
461	414: Increase, Luteinizing hormone (LH)	416: Increase proliferation, Leydig cell	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
1695	459: Increase, Liver steatosis	1115: Increase, ROS	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
3218	459: Increase, Liver steatosis	55: Cell injury/death	May 14, 2024	Jan 30, 2025	1 AOP 494: AhR activation leading to liver fibrosis
3592	459: Increase, Liver steatosis	2019: Non-alcoholic fatty liver disease	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3724	459: Increase, Liver steatosis	2405: Increase, Hepatocellular lipotoxicity	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
3729	344: Increase, Liver fibrosis	2406: Increase, Regenerative nodule formation	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
169	161: Increase, Liver and splenic hemosiderosis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
1599	1445: Increase, LPO	1446: Decrease, Coupling of OXPHOS	Jun 29, 2017	Jun 29, 2017	3 AOPs 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation
2097	1445: Increase, LPO	1772: Decrease, TAG	Apr 30, 2020	Apr 30, 2020	1 AOP 329: Excessive reactive oxygen species production leading to mortality (3)
2210	1445: Increase, LPO	1365: Increase, Apoptosis	Nov 25, 2020	Nov 25, 2020	None
2222	1445: Increase, LPO	1825: Increase, Cell death	Dec 4, 2020	Dec 4, 2020	None
2464	1445: Increase, LPO	1607: Increase, Necrosis	Aug 11, 2021	Aug 11, 2021	1 AOP 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
2879	1445: Increase, LPO	406: decreased, Fertility	Apr 5, 2023	Sep 14, 2023	1 AOP 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress

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