| 2437 |
1903: foxi1 expression, increased |
1904: six1b expression, increased |
Jul 14, 2021 |
Oct 28, 2021 |
1 AOP
|
| 1062 |
976: Formation, The binding of FK506 with FKBP12 |
980: Inhibition, Calcineurin Activity |
Nov 29, 2016 |
Dec 3, 2016 |
None
|
| 344 |
373: Formation, Pro-mutagenic DNA Adducts |
377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H |
Nov 29, 2016 |
Dec 3, 2016 |
None
|
| 345 |
373: Formation, Pro-mutagenic DNA Adducts |
378: Tumorigenesis, Hepatocellular carcinoma |
Nov 29, 2016 |
Nov 29, 2016 |
1 AOP
|
| 352 |
373: Formation, Pro-mutagenic DNA Adducts |
384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci |
Nov 29, 2016 |
Nov 29, 2016 |
None
|
| 548 |
373: Formation, Pro-mutagenic DNA Adducts |
493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 551 |
373: Formation, Pro-mutagenic DNA Adducts |
491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) |
Nov 29, 2016 |
Nov 29, 2016 |
1 AOP
|
| 3762 |
373: Formation, Pro-mutagenic DNA Adducts |
1194: Increase, DNA Damage |
Mar 29, 2026 |
Mar 29, 2026 |
1 AOP
|
| 860 |
839: Formation, Mallory body |
840: Formation, Liver fibrosis |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1854 |
1598: Protein photo-adducts |
1599: Inflammatory events |
Feb 4, 2019 |
Feb 4, 2019 |
None
|
| 1591 |
1440: HDL-SAA formation |
1441: Systemic cholesterol increased |
Jun 29, 2017 |
Jun 29, 2017 |
None
|
| 1593 |
1440: HDL-SAA formation |
1442: Foam cell formation |
Jun 29, 2017 |
Jun 29, 2017 |
None
|
| 1853 |
1597: DNA photo-adducts |
1599: Inflammatory events |
Feb 4, 2019 |
Feb 4, 2019 |
None
|
| 1594 |
1442: Foam cell formation |
1443: Atherosclerosis |
Jun 29, 2017 |
Jun 29, 2017 |
None
|
| 1841 |
1587: Fibroproliferative airway lesions |
1588: Bronchiolitis obliterans |
Jan 30, 2019 |
Jan 30, 2019 |
1 AOP
|
| 2678 |
2012: Fibroblast proliferation and differentiation |
2013: Airway remodeling |
Jun 17, 2022 |
Jun 17, 2022 |
1 AOP
|
| 3707 |
2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced |
2400: Preputial epithelial morphogenesis, disrupted |
Dec 16, 2025 |
Jun 4, 2026 |
1 AOP
|
| 2352 |
1866: Hypofibrinolysis |
1867: Bradykinin, activated |
Apr 20, 2021 |
Apr 20, 2021 |
1 AOP
|
| 2356 |
1866: Hypofibrinolysis |
1496: Increased proinflammatory mediators |
Apr 20, 2021 |
Feb 7, 2023 |
1 AOP
|
| 3296 |
2241: Ferroptosis related pathways activation |
1928: increased，Vascular endothelial dysfunction |
Jul 9, 2024 |
Jul 9, 2024 |
1 AOP
|
| 266 |
240: Feminisation or incomplete development, Primary and accessory male sex organs |
337: N/A, Impairment of reproductive capacity |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1749 |
1528: Fatty Acid Beta Oxidation, Decreased |
861: Decreased, Ketogenesis (production of ketone bodies) |
Jun 11, 2018 |
Jun 11, 2018 |
1 AOP
|
| 1169 |
1130: Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) |
1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 1165 |
1131: Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo |
1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 2686 |
1559: Smaller and morphologically distorted facial cartilage structures |
947: Increase, Early Life Stage Mortality |
Jun 30, 2022 |
Apr 13, 2023 |
1 AOP
|