Key Event Relationships (KERs)

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Showing 2151 to 2175 of 3129 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1430 1317: Decreased, serotonin transporter activity 1320: Increased, extracellular serotonin Apr 14, 2017 Apr 14, 2017
1431 1317: Decreased, serotonin transporter activity 1323: Decreased, intracellular serotonin Apr 14, 2017 Apr 14, 2017
3777 2419: Decreased, RAR activation 1882: Disrupted, meiotic initiation in oocyte Apr 24, 2026 Apr 24, 2026
2635 1141: Decreased, Reproductive Success 360: Decrease, Population growth rate Apr 6, 2022 Apr 6, 2022
830 820: Decreased, Renal plasma flow 814: Occurrence, Kidney toxicity Nov 29, 2016 Dec 3, 2016
832 825: Decreased, Renal ability to dilute urine 814: Occurrence, Kidney toxicity Nov 29, 2016 Dec 3, 2016
3647 968: Decreased, release of kisspeptin from AVPV neurons 530: Decreased, GnRH pulsatility/release Oct 2, 2025 Jan 28, 2026
682 681: Decreased, Prostaglandin F2alpha synthesis, ovary 671: Reduced, Prostaglandin F2alpha concentration, plasma Nov 29, 2016 Dec 3, 2016
1138 1104: Decreased, Prostaglandin F2alpha concentration, plasma 1105: Occurrence, renal ischemia Nov 29, 2016 Dec 3, 2016
3524 747: Decreased, Prolactin 111: Agonism, Estrogen receptor Apr 17, 2025 Apr 17, 2025
1988 1693: Decreased, Progesterone levels 1694: Reduction, progesterone uptake, decresed maturation Oct 3, 2019 Oct 3, 2019
3521 1693: Decreased, Progesterone levels 1611: Reduction, androstenedione Apr 8, 2025 Apr 8, 2025 None
772 749: Decreased, Progesterone from corpus luteum 772: Increase, Hyperplasia (glandular epithelial cells of endometrium) Nov 29, 2016 Dec 3, 2016
3520 2319: Decreased, Pregnenolone levels 1610: Reduction, DHEA Apr 8, 2025 Apr 8, 2025 None
3522 2319: Decreased, Pregnenolone levels 1693: Decreased, Progesterone levels Apr 8, 2025 Apr 8, 2025 None
878 858: Decreased, PPARalpha transactivation of gene expression 859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Nov 29, 2016 Jun 2, 2017 None
879 858: Decreased, PPARalpha transactivation of gene expression 860: Decreased, Mitochondrial Fatty Acid Beta Oxidation Nov 29, 2016 Jun 2, 2017 None
880 858: Decreased, PPARalpha transactivation of gene expression 861: Decreased, Ketogenesis (production of ketone bodies) Nov 29, 2016 Jun 11, 2018
1748 858: Decreased, PPARalpha transactivation of gene expression 1528: Fatty Acid Beta Oxidation, Decreased Jun 11, 2018 Jun 11, 2018
260 233: Decreased, PPAR-gamma activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
3093 233: Decreased, PPAR-gamma activation 1060: Alteration, lipid metabolism Oct 18, 2023 Oct 19, 2023
259 232: Decreased, PPAR-beta activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
257 231: Decreased, PPAR-alpha activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
2042 231: Decreased, PPAR-alpha activation 459: Increase, Liver steatosis Feb 22, 2020 Feb 22, 2020 None
1491 442: Decreased, Population trajectory 351: Increased Mortality Apr 18, 2017 Apr 18, 2017 None