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Showing 2426 to 2450 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2731	2040: Decrease, GLI1/2 target gene expression	2043: Decrease, SHH second messenger production	Aug 23, 2022	Apr 3, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2805	2040: Decrease, GLI1/2 target gene expression	2041: Decrease, facial prominence outgrowth	Nov 17, 2022	Nov 17, 2022	None
2882	2040: Decrease, GLI1/2 target gene expression	1262: Apoptosis	Apr 6, 2023	Apr 4, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
1345	1265: Decrease, Ftz-f1 expression	988: Decrease, Circulating ETH	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
1472	330: Decrease, Fertility	360: Decrease, Population growth rate	Apr 15, 2017	Apr 15, 2017	None
2115	1781: Decrease, Fecundity (F3)	360: Decrease, Population growth rate	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
135	328: Decrease, Fecundity	361: Decline, Population	Nov 29, 2016	Dec 3, 2016	None
1886	328: Decrease, Fecundity	360: Decrease, Population growth rate	Apr 22, 2019	Apr 22, 2019	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2621	328: Decrease, Fecundity	1863: Decrease, Reproduction	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2208	1824: Decrease, FAO	1771: Decrease, ATP pool	Nov 25, 2020	Nov 25, 2020	None
3822	1824: Decrease, FAO	2442: Abnormal lipid accumulation	Jul 9, 2026	Jul 9, 2026	None
3828	1824: Decrease, FAO	2446: lipid accumulation	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
190	179: Decrease, Fatty acid β-oxidation	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	2 AOPs 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
617	179: Decrease, Fatty acid β-oxidation	459: Increase, Liver steatosis	Nov 29, 2016	Dec 3, 2016	None
2931	179: Decrease, Fatty acid β-oxidation	1816: Mitochondrial dysfunction EMPTY	May 25, 2023	May 25, 2023	None
3159	179: Decrease, Fatty acid β-oxidation	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3209	179: Decrease, Fatty acid β-oxidation	2225: Disrupted Lipid Storage	May 8, 2024	May 28, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3635	179: Decrease, Fatty acid β-oxidation	1771: Decrease, ATP pool	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
2726	2041: Decrease, facial prominence outgrowth	2042: orofacial cleft	Jul 28, 2022	May 22, 2023	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
1995	1699: Decease, expression of GnRHR	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Oct 30, 2019	Oct 30, 2019	1 AOP 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1349	1268: Decrease, Excitatory postsynaptic potential	993: Decrease, Abdominal muscle contraction	Feb 9, 2017	Feb 9, 2017	None
3059	2196: Decrease, elavl3	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
1348	1267: Decrease, Ecdysis motor program activity	1268: Decrease, Excitatory postsynaptic potential	Feb 9, 2017	Feb 9, 2017	None
3639	1267: Decrease, Ecdysis motor program activity	993: Decrease, Abdominal muscle contraction	Sep 29, 2025	Sep 29, 2025	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1087	1056: Decrease, E2 blood concentrations at hypothalamus	1047: Increased, secretion of GnRH from hypothalamus	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse

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