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Showing 2526 to 2550 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2372	1498: Loss of alveolar capillary membrane integrity	1250: Decreased lung function	Apr 27, 2021	Apr 27, 2021	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
1972	1675: Loss of barrier function	1676: Blood extravasation into the lungs	Jul 3, 2019	Jul 3, 2019	None
2807	2078: Loss of drebrin	1944: Dysfunctional synapses	Dec 11, 2022	Apr 4, 2025	1 AOP 471: Neuron defect induced early behavioral change
3298	2078: Loss of drebrin	2242: Dendritic spine abnormality	Jul 14, 2024	Apr 4, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3300	2078: Loss of drebrin	341: Impairment, Learning and memory	Jul 14, 2024	Mar 9, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
405	348: Malformation, Male reproductive tract	406: decreased, Fertility	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
808	809: malformed, Male reproductive tract	330: Decrease, Fertility	Nov 29, 2016	Dec 3, 2016	1 AOP 124: HMG-CoA reductase inhibition leading to decreased fertility
402	409: Metabolism of AFB1, Production of Reactive Electrophiles	373: Formation, Pro-mutagenic DNA Adducts	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
3688	2387: Nuclear receptor binding / steroidogenic enzyme interference	2389: Altered steroidogenesis	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3689	2388: photoproducts generate ROS	1392: Increase, Oxidative Stress	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3695	2388: photoproducts generate ROS	2389: Altered steroidogenesis	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3696	2388: photoproducts generate ROS	2363: Mito ROS dysfunction	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
1601	40: Mitochondrial ATP production, decreased	1366: Decrease, Oogenesis	Jun 29, 2017	Jun 29, 2017	None
1670	40: Mitochondrial ATP production, decreased	1478: Decrease, Leaf cell mitosis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1682	40: Mitochondrial ATP production, decreased	709: Increase, Cytotoxicity (renal tubular cell)	Oct 25, 2017	Oct 25, 2017	1 AOP 258: Renal protein alkylation leading to kidney toxicity
1739	40: Mitochondrial ATP production, decreased	1521: Decrease, Growth	May 24, 2018	May 24, 2018	None
1750	40: Mitochondrial ATP production, decreased	1365: Increase, Apoptosis	Jun 12, 2018	Jun 12, 2018	None
1873	40: Mitochondrial ATP production, decreased	1607: Increase, Necrosis	Mar 19, 2019	Mar 19, 2019	None
2551	40: Mitochondrial ATP production, decreased	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
2823	40: Mitochondrial ATP production, decreased	1532: Decrease, Cardiac contractility	Jan 5, 2023	Jan 5, 2023	1 AOP 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
3455	40: Mitochondrial ATP production, decreased	2300: Disruption, Glucolipid metabolism	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3456	40: Mitochondrial ATP production, decreased	2151: Disruption, neurotransmitter release	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3576	40: Mitochondrial ATP production, decreased	2343: Cuproptosis, increased	Aug 13, 2025	Aug 13, 2025	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
1780	1541: Mitochondrial Complex I inhibition	1545: Decrease in mitochondrial oxidative phosphorylation	Dec 19, 2018	Mar 7, 2019	None
3453	1541: Mitochondrial Complex I inhibition	2299: Altered, Redox Homeostasis	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.

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