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Showing 2601 to 2625 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1789	1548: Necrotic Tissue	1549: Liver Injury	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury
1803	1557: Reduced neural crest cell migration	1558: Reduced collagen production	Dec 20, 2018	Dec 20, 2018	1 AOP 274: Histone deacetylase inhibition leads to impeded craniofacial development
2563	1557: Reduced neural crest cell migration	1970: Transposition of the great arteries	Feb 8, 2022	Feb 15, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
208	188: Neuroinflammation	352: N/A, Neurodegeneration	Nov 29, 2016	Feb 23, 2021	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 471: Neuron defect induced early behavioral change
759	188: Neuroinflammation	385: Synaptogenesis, Decreased	Nov 29, 2016	Dec 3, 2016	None
906	188: Neuroinflammation	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Aug 25, 2017	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 471: Neuron defect induced early behavioral change
1687	188: Neuroinflammation	55: Cell injury/death	Nov 9, 2017	Nov 7, 2019	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2288	188: Neuroinflammation	1841: Encephalitis	Feb 23, 2021	Feb 23, 2021	1 AOP 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
2500	188: Neuroinflammation	386: Neuronal network function, Decreased	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2717	188: Neuroinflammation	1825: Increase, Cell death	Jul 25, 2022	Jul 25, 2022	None
3255	188: Neuroinflammation	341: Impairment, Learning and memory	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
210	191: Neuronal dysfunction	188: Neuroinflammation	Nov 29, 2016	Nov 29, 2016	None
2941	191: Neuronal dysfunction	2150: Neurological disorder	Jun 15, 2023	Jun 15, 2023	2 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 471: Neuron defect induced early behavioral change
2457	1915: Neutrophil activation, Increased	1857: Platelet-neutrophil interactions, Increased	Aug 4, 2021	Aug 4, 2021	1 AOP 412: Endothelial cell dysfunction leading to thromboinflammation
1556	1417: NFE2/Nrf2 repression	1419: Reduced, FXR activity	Jun 2, 2017	Jun 2, 2017	1 AOP 232: NFE2/Nrf2 repression to steatosis
2984	1417: NFE2/Nrf2 repression	2162: Activation, HIF1α	Aug 20, 2023	Aug 20, 2023	1 AOP 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
3035	1417: NFE2/Nrf2 repression	2009: Activation, inflammation pathway	Aug 28, 2023	Aug 28, 2023	1 AOP 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
3276	1417: NFE2/Nrf2 repression	1392: Increase, Oxidative Stress	Jul 4, 2024	Jul 4, 2024	2 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
3685	1417: NFE2/Nrf2 repression	2386: Lipid-peroxidation overload	Nov 4, 2025	Nov 4, 2025	None
3712	1417: NFE2/Nrf2 repression	1445: Increase, LPO	Jan 19, 2026	Jan 19, 2026	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
2414	1895: inflammasome activity, increased	1868: Hyperinflammation	Jun 25, 2021	Jun 25, 2021	1 AOP 406: SARS-CoV-2 infection leading to hyperinflammation
2667	2007: Non-coding RNA expression，alteration	2009: Activation, inflammation pathway	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2668	2007: Non-coding RNA expression，alteration	1392: Increase, Oxidative Stress	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2670	2007: Non-coding RNA expression，alteration	2012: Fibroblast proliferation and differentiation	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2671	2007: Non-coding RNA expression，alteration	1262: Apoptosis	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity

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