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Showing 2901 to 2925 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1257	981: Reduction, NFAT/AP-1 complex formation	1204: Suppression, Suppression of T-cell dependent antibody production	Nov 29, 2016	Dec 3, 2016	None
1509	981: Reduction, NFAT/AP-1 complex formation	1202: Suppression, IL-2 and IL-4 production	May 19, 2017	Jun 27, 2021	1 AOP 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
252	219: Reduction, Plasma 17beta-estradiol concentrations	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Mar 20, 2017	5 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
253	219: Reduction, Plasma 17beta-estradiol concentrations	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	Nov 29, 2016	Nov 29, 2016	None
392	219: Reduction, Plasma 17beta-estradiol concentrations	405: disrupted, ovarian cycle	Nov 29, 2016	Dec 3, 2016	1 AOP 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
1386	219: Reduction, Plasma 17beta-estradiol concentrations	221: Reduction, Plasma vitellogenin concentrations	Mar 17, 2017	Oct 18, 2018	7 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
2922	219: Reduction, Plasma 17beta-estradiol concentrations	2139: Reduction, the ratio of E2/11-KT in plasma	May 22, 2023	May 22, 2023	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
255	221: Reduction, Plasma vitellogenin concentrations	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	Nov 29, 2016	Mar 20, 2017	9 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
1769	221: Reduction, Plasma vitellogenin concentrations	78: Reduction, Cumulative fecundity and spawning	Sep 18, 2018	Sep 18, 2018	2 AOPs 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish
1882	221: Reduction, Plasma vitellogenin concentrations	1618: Reduction, egg production and spawning	Apr 18, 2019	Apr 18, 2019	None
1987	1692: Reduction, Progesterone synthesis	1693: Decreased, Progesterone levels	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1989	1694: Reduction, progesterone uptake, decresed maturation	1695: Impaired ovulation	Oct 3, 2019	Oct 3, 2019	1 AOP 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
268	243: Reduction, Prostaglandin E2 concentration	119: N/A, Gap	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
302	274: Reduction, Testosterone synthesis by ovarian theca cells	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
439	413: Reduction, Testosterone synthesis in Leydig cells	446: Reduction of testosterone	Nov 29, 2016	Dec 2, 2016	None
2125	413: Reduction, Testosterone synthesis in Leydig cells	1690: Decrease, circulating testosterone levels	May 11, 2020	May 1, 2024	3 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
2923	2139: Reduction, the ratio of E2/11-KT in plasma	221: Reduction, Plasma vitellogenin concentrations	May 22, 2023	May 22, 2023	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
3393	2139: Reduction, the ratio of E2/11-KT in plasma	2137: Increase, Gonadotropins concentration in plasma	Nov 16, 2024	Nov 16, 2024	1 AOP 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
337	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Mar 20, 2017	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3396	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	1467: Growth, reduction	Nov 16, 2024	Nov 16, 2024	1 AOP 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
315	285: Reduction, Vitellogenin synthesis in liver	221: Reduction, Plasma vitellogenin concentrations	Nov 29, 2016	Mar 20, 2017	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
1081	1040: relaxation, smooth muscle	1042: Proliferation/Clonal Expansion, smooth muscle	Nov 29, 2016	Dec 3, 2016	1 AOP 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1564	1426: Release of G Proteins	1427: Opening of GIRK channels	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
1568	1426: Release of G Proteins	1429: Inhibition of Ca Channels	Jun 23, 2017	Jun 23, 2017	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
108	87: Release, Cytokine	149: Increase, Inflammation	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)

Key Event Relationships (KERs)

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