Key Event Relationships (KERs)

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Showing 1251 to 1275 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3383 2252: Formation of HLA-DQ2/8-gluten complexes 2275: Co-localization of gluten reactive adaptive T-cells with APC Nov 12, 2024 Apr 8, 2025
2326 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1752: Increased AngII Apr 10, 2021 Apr 10, 2021
2521 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1535: Heart failure Oct 28, 2021 Oct 28, 2021 None
2762 1868: Hyperinflammation 1748: Increase, the risk of acute respiratory failure Sep 1, 2022 Sep 1, 2022 None
3429 2289: RyR2 hyperphosphorylation 389: Increased, Intracellular Calcium overload Nov 22, 2024 Nov 22, 2024
158 142: Hyperplasia, Hyperplasia 334: Promotion, Hepatocelluar carcinoma Nov 29, 2016 Dec 3, 2016
462 415: Hyperplasia, Leydig cell 406: decreased, Fertility Nov 29, 2016 Dec 3, 2016
1115 1078: Hyperplasia, Mammary gland 1080: Increased, latency period Nov 29, 2016 Dec 3, 2016
1116 1078: Hyperplasia, Mammary gland 1079: Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
1093 1052: Hyperplasia, ovarian epithelium 1053: Promotion, ovarian adenomas Nov 29, 2016 Dec 3, 2016
1094 1051: Hyperplasia, ovarian stromal cells 1054: Promotion, ovarian granular cell tumors Nov 29, 2016 Dec 3, 2016
755 763: hyperpolarisation, neuron 764: N/A, Ataxia, paralysis, or hyperactivity Nov 29, 2016 Dec 3, 2016
1566 763: hyperpolarisation, neuron 1428: Analgesia Jun 8, 2017 Jun 8, 2017
1572 763: hyperpolarisation, neuron 1432: Anti-depressant Activity Jun 23, 2017 Jun 23, 2017
1083 1043: Hypertrophy/hyperplasia, smooth muscle 1044: Promotion, mesovarian leiomyomas Nov 29, 2016 Dec 3, 2016
3191 2107: Hypomyelination 2108: Altered, white brain matter Apr 12, 2024 Apr 12, 2024
2197 1819: IFNγ signaling 1633: Increase in inflammation Nov 2, 2020 Nov 2, 2020
2318 1856: Sodium inhibition, Sweet enhancement 1849: Impaired gustatory nerve Apr 10, 2021 Apr 10, 2021
2196 1818: Immune cell activation 1819: IFNγ signaling Nov 2, 2020 Nov 2, 2020
3054 2180: immune mechanisms antagonized 2192: IAV production increased Oct 3, 2023 Oct 3, 2023
1278 1225: Leukocyte infiltration 1226: Respiratory irritability Nov 29, 2016 Dec 3, 2016 None
1290 1225: Leukocyte infiltration 1237: Sensitization, Immune system Nov 29, 2016 Dec 3, 2016 None
1923 1644: Impaired Ab production 986: Impairment of TDAR May 23, 2019 Jun 25, 2019 None
1820 1568: Impaired antigen presentation 1569: Impaired T cell activation Dec 25, 2018 Dec 25, 2018 None
3665 2378: Impaired axonal insulation 386: Neuronal network function, Decreased Oct 8, 2025 Oct 8, 2025