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All KERs

Showing 1551 to 1575 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1417	1312: Increase, Fatty acid β-oxidation	1313: Decrease, cytosolic fatty acid	Apr 13, 2017	Apr 13, 2017	None
3676	1312: Increase, Fatty acid β-oxidation	1446: Decrease, Coupling of OXPHOS	Oct 30, 2025	Oct 30, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
132	115: Increase, FA influx	291: Accumulation, Triglyceride	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
3723	115: Increase, FA influx	459: Increase, Liver steatosis	Feb 10, 2026	Feb 10, 2026	None
3687	1994: Ferroptosis	902: Inflammation, Liver	Nov 4, 2025	Nov 4, 2025	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
1597	1444: Increase, Follicular atresia	1366: Decrease, Oogenesis	Jun 29, 2017	Jun 29, 2017	2 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia
2211	1444: Increase, Follicular atresia	328: Decrease, Fecundity	Nov 25, 2020	Nov 25, 2020	None
3097	1765: Increase, Formation of DNA photoproducts	1461: Increase, DSB	Nov 16, 2023	Nov 16, 2023	None
1462	1361: Increase, GABA	1359: Activate, GABA-A receptor	Apr 14, 2017	Apr 14, 2017	1 AOP 215: Molecular events lead to epilepsy
1885	1621: Increase, Gene expression	328: Decrease, Fecundity	Apr 22, 2019	Apr 22, 2019	None
1234	1175: Increase, Genes involved in fatty acid oxidation	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
1240	1175: Increase, Genes involved in fatty acid oxidation	1173: Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	Nov 29, 2016	Dec 3, 2016	None
2226	1827: Increase, Global methylation	1365: Increase, Apoptosis	Dec 4, 2020	Dec 4, 2020	None
385	122: Increase, GR activation	145: Induction, IKB inhibitory protein	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
1451	122: Increase, GR activation	1335: Reduced, BDNF	Apr 14, 2017	Apr 14, 2017	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
2039	122: Increase, GR activation	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Feb 22, 2020	Feb 22, 2020	None
2041	122: Increase, GR activation	231: Decreased, PPAR-alpha activation	Feb 22, 2020	Feb 22, 2020	None
2261	122: Increase, GR activation	54: Up Regulation, CD36	Jan 15, 2021	Jan 15, 2021	None
2266	122: Increase, GR activation	1834: Decrease, ACAD	Jan 15, 2021	Jan 15, 2021	1 AOP 318: Glucocorticoid Receptor activation leading to hepatic steatosis
3526	122: Increase, GR activation	2245: Altered cell differentiation signaling	Apr 18, 2025	Apr 18, 2025	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
3738	122: Increase, GR activation	2119: Increase, Insulin resistance	Feb 12, 2026	Feb 12, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
3739	122: Increase, GR activation	450: Decrease, VLDL export capacity	Feb 12, 2026	Feb 12, 2026	None
3740	122: Increase, GR activation	1306: Increase, De novo lipogenesis	Feb 12, 2026	Feb 12, 2026	3 AOPs 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2885	2133: Increase, Glucuronidation of T4	961: Increased, Clearance of thyroxine from serum	Apr 12, 2023	Apr 12, 2023	None
2794	2070: Increase, Glycolysis	2071: Decrease, Glucose pool	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion

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