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Showing 1601 to 1625 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2018	1707: Increase of IL-23	1708: Th17 cell migration and inflammation induction	Dec 27, 2019	Dec 27, 2019	1 AOP 313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1002	990: Increase, Incomplete ecdysis	350: Increase, Mortality	Nov 29, 2016	Dec 3, 2016	4 AOPs 466: Doda decarboxylase leading to mortality 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
1190	990: Increase, Incomplete ecdysis	351: Increased Mortality	Nov 29, 2016	Dec 3, 2016	None
2750	990: Increase, Incomplete ecdysis	2056: Increase, delay in oviposition	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
2751	990: Increase, Incomplete ecdysis	2057: Decrease, hatching of egg	Aug 28, 2022	Aug 28, 2022	1 AOP 466: Doda decarboxylase leading to mortality
2759	990: Increase, Incomplete ecdysis	2050: Increase, developmental abnormalities	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
781	149: Increase, Inflammation	781: Increase, Regenerative cell proliferation (forestomach epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
929	149: Increase, Inflammation	357: Cholestasis, Pathology	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
1722	149: Increase, Inflammation	1273: Expression of Collagen	Mar 18, 2018	Mar 18, 2018	None
1724	149: Increase, Inflammation	1457: EMT	Mar 18, 2018	Jan 30, 2019	2 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans
1839	149: Increase, Inflammation	1587: Fibroproliferative airway lesions	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
2573	149: Increase, Inflammation	1196: Increased, Invasion	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2574	149: Increase, Inflammation	1376: Increase, angiogenesis	Feb 15, 2022	Dec 20, 2022	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2976	149: Increase, Inflammation	1513: General Apoptosis	Jul 31, 2023	Oct 19, 2023	1 AOP 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
3357	149: Increase, Inflammation	2265: Oligodendrocyte death, increased	Oct 1, 2024	Oct 1, 2024	1 AOP 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3358	149: Increase, Inflammation	2266: Demyelination, increased	Oct 1, 2024	Oct 1, 2024	1 AOP 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation
3764	149: Increase, Inflammation	1825: Increase, Cell death	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
778	777: Increase, Inflammation (corneal cells)	778: Increase, Regenerative cell proliferation (corneal cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
1440	1338: Increase, inositol triphosphate	1339: Increase, intracellular calcium	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1390	1296: Increase, insulin	1297: Activation, insulin receptor	Apr 12, 2017	Apr 12, 2017	None
3178	2119: Increase, Insulin resistance	2129: Metabolically unhealthy Obesity	Apr 9, 2024	Apr 9, 2024	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
3180	2119: Increase, Insulin resistance	2145: Metabolic syndrome	Apr 9, 2024	Apr 9, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3721	2119: Increase, Insulin resistance	2408: Increase, Adipose lipolysis	Feb 10, 2026	Feb 10, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
1441	1339: Increase, intracellular calcium	1340: Activate, calmodulin	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
2954	1339: Increase, intracellular calcium	2151: Disruption, neurotransmitter release	Jun 27, 2023	Apr 11, 2024	1 AOP 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release

Key Event Relationships (KERs)

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