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Showing 2051 to 2075 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2728	1669: Increased, DNA damage and mutation	1554: Increase chromosomal aberrations	Aug 14, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1366	1281: Increased, DNA Damage-Repair	1262: Apoptosis	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3594	1281: Increased, DNA Damage-Repair	2354: Activation, Apoptosis signaling	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1252	1192: Increased, Ductal Hyperplasia	1193: N/A, Breast Cancer	Nov 29, 2016	May 8, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1157	1110: Increased, Energetic demands and therefore metabolic stress	560: Abnormal, Foraging activity and behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 183: Nosema infection increases energetic demands leading to colony loss/failure
3082	1363: Increased, epilepsy	350: Increase, Mortality	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
1250	1187: Increased, ER binding to DNA (classical pathway)	1182: Increase, Cell Proliferation (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1296	1187: Increased, ER binding to DNA (classical pathway)	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1251	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	1182: Increase, Cell Proliferation (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1297	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	1239: Altered, Gene Expression	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
3115	2205: Increased, essential element imbalance	1115: Increase, ROS	Jan 24, 2024	Aug 2, 2024	1 AOP 521: Essential element imbalance leads to reproductive failure via oxidative stress
3717	2402: Increased, E2 production in ovaries	2294: Plasma E2, increased	Jan 29, 2026	Feb 3, 2026	3 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release
2737	748: Increased, Estrogen receptor (ER) activity	2046: Increase, Vitellogenin mRNA	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2583	1973: Increased, estrogens	1076: Increased, circulating estrogen levels	Feb 26, 2022	Mar 1, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
3104	2199: Increased, Expression of LXR activated genes	89: Synthesis, De Novo Fatty Acid (FA)	Dec 7, 2023	Mar 29, 2024	1 AOP 518: Liver X Receptor (LXR) activation leads to liver steatosis
1521	1320: Increased, extracellular serotonin	1347: Decreased, extracellular serotonin	May 30, 2017	May 30, 2017	None
1529	1320: Increased, extracellular serotonin	1401: Decreased, 5-HT3	Jun 1, 2017	Jun 1, 2017	1 AOP 223: Serotonin transporter activation to seizure
1531	1320: Increased, extracellular serotonin	1336: Activation, 5-HT2A	Jun 2, 2017	Jun 2, 2017	1 AOP 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
3475	1320: Increased, extracellular serotonin	2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors	Jan 14, 2025	Feb 20, 2025	1 AOP 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
3489	1320: Increased, extracellular serotonin	1016: Inhibition, Feeding	Feb 20, 2025	Feb 20, 2025	1 AOP 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
504	465: Increased, FA Influx	291: Accumulation, Triglyceride	Nov 29, 2016	Dec 3, 2016	None
505	465: Increased, FA Influx	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	3 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1658	465: Increased, FA Influx	454: Increased, Triglyceride formation	Aug 31, 2017	Aug 31, 2017	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
3744	465: Increased, FA Influx	459: Increase, Liver steatosis	Feb 24, 2026	Feb 24, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
2263	460: Increased, Fatty acid uptake	459: Increase, Liver steatosis	Jan 15, 2021	Jan 15, 2021	None

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