AOP-Wiki

API

All Key Events

Showing 776 to 800 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1607	Increase, Necrosis Short Name Increase, Necrosis	0	Tissue	Mar 19, 2019	Mar 19, 2019	413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
1606	Activation, Stellate cell Short Name Activation, Stellate cell	0	Cellular	Mar 6, 2019	Feb 11, 2026	285: Inhibition of N-linked glycosylation leads to liver injury
1605	Accumulation of misfolded proteins Short Name Accumulation, misfolded proteins	0	Cellular	Mar 6, 2019	Mar 6, 2019	2 AOPs 285: Inhibition of N-linked glycosylation leads to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1604	Inhibition of N-linked glycosylation Short Name Inhibition of N-linked glycosylation	0	Molecular	Mar 6, 2019	Mar 6, 2019	285: Inhibition of N-linked glycosylation leads to liver injury
1603	Chronic kidney disease Short Name Chronic kidney disease	0	Organ	Feb 18, 2019	Feb 18, 2019	2 AOPs 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1602	Increased Muscarinic Acetylcholine Receptors Short Name	1	Molecular	Feb 6, 2019	Dec 2, 2024	3 AOPs 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
1601	Scaling, Lichenification Short Name Scaling, Lichenification	0	Organ	Feb 3, 2019	Feb 3, 2019	None
1600	Eczematous eruption (Erythema, Papules, Vesicles, Pruritius, Weeping, Oozing, Crusting) Short Name Eczematous eruption	0	Organ	Feb 3, 2019	Feb 3, 2019	None
1599	Inflamatory events in light-exposed tissues Short Name Inflammatory events	0	Organ	Feb 3, 2019	Jul 4, 2019	2 AOPs 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure 495: Androgen receptor activation leading to prostate cancer
1598	Formation of protein photo-adducts Short Name Protein photo-adducts	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1597	Formation of DNA photo-adducts Short Name DNA photo-adducts	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1596	Oxidation of DNA Short Name Oxidation of DNA	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1595	Oxidation/denatuation of membrane proteins Short Name	0	Cellular	Feb 3, 2019	Jul 4, 2019	282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1594	Oxidation of membrane lipids Short Name Oxidation of membrane lipids	0	Cellular	Feb 3, 2019	Jul 4, 2019	282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1593	Radicals of target chemicals Short Name Radical generation	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1591	Absorption of photon energy Short Name Absorption of photon energy	0	Molecular	Feb 3, 2019	Feb 5, 2019	None
1590	Distribution and deposition of chemicals to skin and/or eyes Short Name Distribution of chemicals	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1589	Systemic or topical administration of chemicals Short Name Administration of chemicals	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1588	Bronchiolitis obliterans Short Name Bronchiolitis obliterans	0	Individual	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1587	Fibroproliferative airway lesions Short Name Fibroproliferative airway lesions	0	Tissue	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1586	Airway epithelial injury Short Name Airway epithelial injury	0	Cellular	Jan 30, 2019	Jan 30, 2019	2 AOPs 280: α-diketone-induced bronchiolitis obliterans 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1585	Proteasomal dysfunction Short Name Proteasomal dysfunction	0	Molecular	Jan 30, 2019	Jan 30, 2019	2 AOPs 280: α-diketone-induced bronchiolitis obliterans 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1584	Interaction of α-diketones with arginine residues Short Name	0	Molecular	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1583	Sensory axonal peripheral neuropathy Short Name Sensory axonal peripheral neuropathy	0	Individual	Jan 29, 2019	Jan 29, 2019	3 AOPs 279: Microtubule interacting drugs lead to peripheral neuropathy 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change
1582	Impaired axonial transport Short Name Impaired axonial transport	0	Cellular	Jan 29, 2019	Jan 29, 2019	3 AOPs 279: Microtubule interacting drugs lead to peripheral neuropathy 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 471: Neuron defect induced early behavioral change