AOP-Wiki

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All Key Events

Showing 976 to 1000 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1397	Increased, serotonin transporter activity Short Name	0	Cellular	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1396	Increased, glucocorticoid receptor activity Short Name	0	Molecular	May 31, 2017	May 31, 2017	2 AOPs 221: Mental stress to depression 222: Mental stress to agitation
1395	Liver Cancer Short Name Liver Cancer	0	Organ	May 30, 2017	Jun 19, 2021	2 AOPs 220: Cyp2E1 Activation Leading to Liver Cancer 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1394	Induction, persistent proliferation/sustained proliferation Short Name Sustained proliferation	4	Cellular	May 30, 2017	Jun 19, 2021	220: Cyp2E1 Activation Leading to Liver Cancer
1393	Hepatocytotoxicity Short Name Hepatocytotoxicity	0	Cellular	May 30, 2017	Jun 19, 2021	220: Cyp2E1 Activation Leading to Liver Cancer
1392	Increase, Oxidative Stress Short Name Increase, Oxidative Stress	1	Molecular	May 30, 2017	Feb 11, 2026	68 AOPs 220: Cyp2E1 Activation Leading to Liver Cancer 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 452: Adverse outcome pathway of PM-induced respiratory toxicity 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 470: Deposition of energy leads to abnormal vascular remodeling 478: Deposition of energy leading to occurrence of cataracts 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 482: Deposition of energy leading to occurrence of bone loss 483: Deposition of Energy Leading to Learning and Memory Impairment 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress 26: Calcium-mediated neuronal ROS production and energy imbalance 488: Increased reactive oxygen species production leading to decreased cognitive function 396: Deposition of ionizing energy leads to population decline via impaired meiosis 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 535: Binding and activation of GPER leading to learning and memory impairments 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 200: Estrogen receptor activation leading to breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 501: Excessive iron accumulation leading to neurological disorders 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 471: Neuron defect induced early behavioral change 31: Oxidation of iron in hemoglobin leading to hematotoxicity 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 462: Activation of reactive oxygen species leading the atherosclerosis 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 595: Emerging OPFRS reproductive outcome pathway 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination 616: organic UV filter and its Photoproducts reproductive toxicity pathways 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 472: DNA adduct formation leading to kidney failure 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
1391	Activation of Cyp2E1 Short Name Activation of Cyp2E1	0	Molecular	May 30, 2017	Jun 19, 2021	2 AOPs 220: Cyp2E1 Activation Leading to Liver Cancer 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
1390	Sexual behavior, decreased Short Name Sexual behavior, decreased	0	Individual	May 3, 2017	May 17, 2017	219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1389	Locomotor activity, decreased Short Name Locomotor activity, decreased	0	Individual	May 2, 2017	May 18, 2017	218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
1388	Dopamine release in the brain, decreased Short Name	0	Tissue	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1387	7α-hydroxypregnenolone synthesis in the brain, decreased Short Name	0	Cellular	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1386	CYP7B activity, inhibition Short Name CYP7B activity, inhibition	0	Molecular	May 2, 2017	May 17, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1385	Activated, gastric ulcer formation Short Name Activated, gastric ulcer formation	0	Organ	Apr 17, 2017	Jun 2, 2017	4 AOPs 217: Gastric ulcer formation 227: NSAID induced PTGS1 inactivation to gastric ulcer 228: NSAID induced PTGS2 inactivation to gastric ulcer 229: Helicobacter pylori to gastric ulcer
1384	Increase, ammonium (NH4+) Short Name Increase, ammonium (NH4+)	0	Molecular	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
1383	Activate, phospholipase Short Name Activate, phospholipase	0	Molecular	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
1382	Decrease, surfactant Short Name Decrease, surfactant	0	Molecular	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer
1381	Increase, surfactant Short Name Increase, surfactant	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1380	Activate, mucosal defense Short Name Activate, mucosal defense	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1379	Activate, leukocyte Short Name Activate, leukocyte	0	Cellular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1378	Increase, leukocyte adherence Short Name Increase, leukocyte adherence	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1377	Decrease, leukocyte adherence Short Name Decrease, leukocyte adherence	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1376	Increase, angiogenesis Short Name Increase, angiogenesis	1	Tissue	Apr 17, 2017	Feb 29, 2024	2 AOPs 217: Gastric ulcer formation 439: Activation of the AhR leading to metastatic breast cancer
1375	Increase, platelet aggregation Short Name Increase, platelet aggregation	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1374	Increase, mucosal blood flow Short Name Increase, mucosal blood flow	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1373	Increase, mucous Short Name Increase, mucous	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation