AOP-Wiki

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All Key Events

Showing 1401 to 1425 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

944	dimerization, AHR/ARNT Short Name dimerization, AHR/ARNT	2	Molecular	Nov 29, 2016	May 31, 2025	7 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
943	Hypersecretion, Mucus Short Name Hypersecretion, Mucus	0	Organ	Nov 29, 2016	Nov 29, 2016	None
941	Activation, EGFR Short Name Activation, EGFR	2	Molecular	Nov 29, 2016	Mar 8, 2023	148: EGFR Activation Leading to Decreased Lung Function
937	KE7 : Impaired, Vasodilation Short Name Impaired, Vasodilation	1	Organ	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
935	KE2 : Decrease, GTPCH-1 Short Name Decrease, GTPCH-1	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
934	KE3 : Decrease, Tetrahydrobiopterin Short Name Decrease, Tetrahydrobiopterin	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
933	KE6 : Depletion, Nitric Oxide Short Name Depletion, Nitric Oxide	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
932	KE4 : Uncoupling, eNOS Short Name Uncoupling, eNOS	1	Cellular	Nov 29, 2016	Nov 9, 2017	2 AOPs 149: Peptide Oxidation Leading to Hypertension 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
927	KE1 : S-Glutathionylation, eNOS Short Name S-Glutathionylation, eNOS	2	Molecular	Nov 29, 2016	Nov 20, 2017	149: Peptide Oxidation Leading to Hypertension
926	Oxidation, Glutathione (To be considered with MIE) Short Name Oxidation, Glutathione	1	Molecular	Nov 29, 2016	Nov 9, 2017	2 AOPs 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
924	Activation, Sp1 Short Name Activation, Sp1	1	Molecular	Nov 29, 2016	Aug 20, 2021	None
923	Increase, Proliferation of goblet cells Short Name Increased goblet cell proliferation	1	Cellular	Nov 29, 2016	Aug 20, 2021	None
921	Occurrence, Hyperplasia of goblet cells Short Name Goblet cell hyperplasia	1	Tissue	Nov 29, 2016	Sep 21, 2021	None
920	Occurrence, Metaplasia of goblet cells Short Name Goblet cell metaplasia	1	Tissue	Nov 29, 2016	Aug 23, 2021	None
919	Occurrence, Transdifferentiation of ciliated epithelial cells Short Name	1	Cellular	Nov 29, 2016	Aug 17, 2021	None
914	Decrease, Apoptosis of ciliated epithelial cells Short Name Decreased ciliated cell apoptosis	1	Cellular	Nov 29, 2016	Aug 17, 2021	None
913	Activation, Epidermal Growth Factor Receptor Short Name	0		Nov 29, 2016	Nov 29, 2016	None
907	Infiltration, Inflammatory cytokines Short Name Infiltration, Inflammatory cytokines	0		Nov 29, 2016	Nov 29, 2016	None
902	Inflammation, Liver Short Name Inflammation, Liver	1	Organ	Nov 29, 2016	Sep 16, 2017	3 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
901	Infiltration, Inflammatory cells Short Name Infiltration, Inflammatory cells	1	Tissue	Nov 29, 2016	Sep 16, 2017	462: Activation of reactive oxygen species leading the atherosclerosis
898	Disruption, Lysosome Short Name Disruption, Lysosome	1	Cellular	Nov 29, 2016	Aug 29, 2024	3 AOPs 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
896	Parkinsonian motor deficits Short Name Parkinsonian motor deficits	1	Individual	Nov 29, 2016	Mar 12, 2018	7 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 471: Neuron defect induced early behavioral change 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
890	Degeneration of dopaminergic neurons of the nigrostriatal pathway Short Name	1	Organ	Nov 29, 2016	Oct 1, 2025	6 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 471: Neuron defect induced early behavioral change 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
889	Proteostasis, impaired Short Name Proteostasis, impaired	1	Cellular	Nov 29, 2016	Oct 16, 2025	4 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 273: Mitochondrial complex inhibition leading to liver injury 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
888	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Short Name	1	Molecular	Nov 29, 2016	Mar 28, 2018	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury