AOP-Wiki

API

All Key Events

Showing 1426 to 1450 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

887	Inhibition, NADH-ubiquinone oxidoreductase (complex I) Short Name	1	Cellular	Nov 29, 2016	Oct 3, 2025	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
885	Increase, Cancer Short Name Increase, Cancer	1	Tissue	Nov 29, 2016	Aug 22, 2023	6 AOPs 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
881	Increased, Triglyceride Short Name Increased, Triglyceride	1	Cellular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
880	Increased, ApoB100 Short Name Increased, ApoB100	1	Tissue	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
879	Activation, MTTP Short Name Activation, MTTP	1	Cellular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
878	Inhibition, SREBP1c Short Name Inhibition, SREBP1c	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
877	Inhibition, organic anion transporter 1 (OAT1) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
876	Increase, Mutations in Critical Genes Short Name Increase, Mutations in Critical Genes	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
875	Binding of agonist, Ionotropic glutamate receptors Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
872	Increase, Site of Contact Nasal Tumors Short Name Increase, Site of Contact Nasal Tumors	1	Organ	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
870	Increase, Cell Proliferation Short Name Increase, Cell Proliferation	2	Cellular	Nov 29, 2016	Dec 10, 2024	9 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 303: Frustrated phagocytosis-induced lung cancer 272: Deposition of energy leading to lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 451: Interaction with lung resident cell membrane components leads to lung cancer 478: Deposition of energy leading to occurrence of cataracts 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
869	Increase, Respiratory or Squamous Metaplasia Short Name	1	Tissue	Nov 29, 2016	Sep 29, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
868	Increase, Tissue Degeneration, Necrosis & Atrophy Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
867	Decrease, Intracellular pH Short Name Decrease, Intracellular pH	1	Cellular	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
864	Decreased, Body Weight Short Name Decreased, Body Weight	1	Individual	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
863	Increased, Catabolism of Muscle Protein Short Name Increased, Catabolism of Muscle Protein	1	Organ	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
862	Not Increased, Circulating Ketone Bodies Short Name	2	Tissue	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
861	Decreased, Ketogenesis (production of ketone bodies) Short Name	1	Cellular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
860	Decreased, Mitochondrial Fatty Acid Beta Oxidation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	318: Glucocorticoid Receptor activation leading to hepatic steatosis
859	Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
858	Decreased, PPARalpha transactivation of gene expression Short Name	1	Molecular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
857	Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain Short Name	0	Molecular	Nov 29, 2016	Nov 29, 2016	None
856	Formation, Hepatocellular and Bile duct tumors Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	41: Sustained AhR Activation leading to Rodent Liver Tumours
854	Alterations, Cellular proliferation / hyperplasia Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 41: Sustained AhR Activation leading to Rodent Liver Tumours 495: Androgen receptor activation leading to prostate cancer
853	Changes/Inhibition, Cellular Homeostasis and Apoptosis Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	41: Sustained AhR Activation leading to Rodent Liver Tumours