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All Key Events

Showing 1751 to 1775 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

376	Increased, Induced Mutations in Critical Genes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
373	Formation, Pro-mutagenic DNA Adducts Short Name Formation, Pro-mutagenic DNA Adducts	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) 472: DNA adduct formation leading to kidney failure
369	Uroporphyria Short Name Uroporphyria	1	Individual	Nov 29, 2016	May 7, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
366	Increased, Structural malformations Short Name Increased, Structural malformations	0		Nov 29, 2016	Nov 29, 2016	None
364	Impaired development of, Reproductive organs Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 616: organic UV filter and its Photoproducts reproductive toxicity pathways
363	Altered, Reproductive behaviour Short Name Altered, Reproductive behaviour	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 616: organic UV filter and its Photoproducts reproductive toxicity pathways
361	Decline, Population Short Name Decline, Population	1	Population	Nov 29, 2016	Dec 3, 2016	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
360	Decrease, Population growth rate Short Name Decrease, Population growth rate	1	Population	Nov 29, 2016	Jan 3, 2023	61 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 25: Aromatase inhibition leading to reproductive dysfunction 29: Estrogen receptor agonism leading to reproductive dysfunction 30: Estrogen receptor antagonism leading to reproductive dysfunction 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 63: Cyclooxygenase inhibition leading to reproductive dysfunction 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 292: Inhibition of tyrosinase leads to decreased population in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2) 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 376: Androgen receptor agonism leading to male-biased sex ratio 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
358	Increase, Pericardial edema Short Name Increase, Pericardial edema	1	Organ	Nov 29, 2016	Sep 16, 2017	None
357	Cholestasis, Pathology Short Name Cholestasis, Pathology	1	Individual	Nov 29, 2016	Dec 3, 2016	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
352	N/A, Neurodegeneration Short Name N/A, Neurodegeneration	1	Tissue	Nov 29, 2016	Feb 23, 2021	7 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 471: Neuron defect induced early behavioral change
351	Increased Mortality Short Name Increased Mortality	1	Population	Nov 29, 2016	Jul 8, 2022	28 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 96: Axonal sodium channel modulation leading to acute mortality 104: Altered ion channel activity leading impaired heart function 113: Glutamate-gated chloride channel activation leading to acute mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination
350	Increase, Mortality Short Name Increase, Mortality	1	Individual	Nov 29, 2016	Oct 26, 2020	16 AOPs 327: Excessive reactive oxygen species production leading to mortality (1) 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 465: Alcohol dehydrogenase leading to reproductive dysfunction 466: Doda decarboxylase leading to mortality 467: Knickkopf leading to mortality 471: Neuron defect induced early behavioral change 330: Excessive reactive oxygen species production leading to mortality (4) 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
348	Malformation, Male reproductive tract Short Name Malformation, Male reproductive tract	1	Organ	Nov 29, 2016	Sep 16, 2017	18: PPARα activation in utero leading to impaired fertility in males
347	Formation, Liver tumor Short Name Formation, Liver tumor	1	Individual	Nov 29, 2016	Dec 3, 2016	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
345	N/A, Liver Steatosis Short Name N/A, Liver Steatosis	1	Organ	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
344	Increase, Liver fibrosis Short Name Increase, Liver fibrosis	1	Organ	Nov 29, 2016	Feb 11, 2026	11 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 494: AhR activation leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
342	Increased, Lethality Short Name Increased, Lethality	0		Nov 29, 2016	Nov 29, 2016	None
341	Impairment, Learning and memory Short Name Impairment, Learning and memory	2	Individual	Nov 29, 2016	Apr 27, 2026	22 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 99: Histamine (H2) receptor antagonism leading to reduced survival 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 483: Deposition of Energy Leading to Learning and Memory Impairment 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory 535: Binding and activation of GPER leading to learning and memory impairments 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
339	Altered, Larval development Short Name Altered, Larval development	1	Individual	Nov 29, 2016	Dec 3, 2016	29: Estrogen receptor agonism leading to reproductive dysfunction
337	N/A, Impairment of reproductive capacity Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
336	Increase, Heritable mutations in offspring Short Name	1	Individual	Nov 29, 2016	Nov 29, 2016	15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
334	Promotion, Hepatocelluar carcinoma Short Name Promotion, Hepatocelluar carcinoma	1	Individual	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
330	Decrease, Fertility Short Name Decrease, Fertility	1	Individual	Nov 29, 2016	Jun 29, 2017	124: HMG-CoA reductase inhibition leading to decreased fertility
328	Decrease, Fecundity Short Name Decrease, Fecundity	0	Individual	Nov 29, 2016	Jun 12, 2018	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability