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Showing 2851 to 2875 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

685	685: Reduced, Prostaglandins, ovary	488: Decrease, Ovulation	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
1532	1402: Reduced, PTGS1 function	1403: Reduced, platelet aggregation	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1534	1402: Reduced, PTGS1 function	1404: Decreased, mucosal blood flow	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1537	1402: Reduced, PTGS1 function	1406: Decreased, mucous	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1539	1402: Reduced, PTGS1 function	1407: Decreased, bicarbonate	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1541	1408: Reduced, PTGS2 function	1409: Decreased, angiogenesis	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
1543	1408: Reduced, PTGS2 function	1410: Increased, leukocyte adherence	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
675	675: Reduced, Reproductive Success	360: Decrease, Population growth rate	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 63: Cyclooxygenase inhibition leading to reproductive dysfunction 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
1558	1420: Reduced, SHP activity	1421: Activated, LXR	Jun 2, 2017	Jun 2, 2017	1 AOP 232: NFE2/Nrf2 repression to steatosis
673	673: Reduced, Spawning behavior	674: Reduced, Ability to attract spawning mates	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
1641	1005: Reduced, Swimming performance	1467: Growth, reduction	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1642	1005: Reduced, Swimming performance	636: Decreased, survival	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
2081	1005: Reduced, Swimming performance	360: Decrease, Population growth rate	Apr 21, 2020	Jun 4, 2020	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2212	1005: Reduced, Swimming performance	351: Increased Mortality	Nov 30, 2020	Sep 8, 2021	5 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
3674	1005: Reduced, Swimming performance	2382: Increase, nerve spasm	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
587	586: Reduced, swimming speed	587: Reduced, feeding 1	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
588	586: Reduced, swimming speed	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation
1895	1631: Reduction fo Pigmentation pattern	360: Decrease, Population growth rate	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
1893	1629: Reduction in melanin level	1630: Reduction of melanosome level	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
396	408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1)	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Nov 29, 2016	1 AOP 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
1638	1464: Reduction of collagen crosslinking	1465: Weak collagen matrix	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1892	1628: Reduction of L-Dopaquinone	1629: Reduction in melanin level	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
1894	1630: Reduction of melanosome level	1631: Reduction fo Pigmentation pattern	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
5	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	219: Reduction, Plasma 17beta-estradiol concentrations	Nov 29, 2016	Mar 20, 2017	6 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
3326	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	285: Reduction, Vitellogenin synthesis in liver	Jul 26, 2024	Jul 26, 2024	1 AOP 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production

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