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All KERs

Showing 2876 to 2900 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3624	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	1696: Decrease of egg production and cummulative fecundity	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
2145	1789: Reduction, E2 Synthesis by the undifferentiated gonad	1790: Increased, Differentiation to Testis	Jun 15, 2020	Jul 11, 2022	1 AOP 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
3229	1611: Reduction, androstenedione	1690: Decrease, circulating testosterone levels	May 24, 2024	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
36	28: Reduction, Angiogenesis	110: Impairment, Endothelial network	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
3683	28: Reduction, Angiogenesis	2383: Increase, Hemopericardium	Oct 30, 2025	Oct 30, 2025	1 AOP 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
59	49: Reduction, Ca and HCO3 transport to shell gland	106: Reduction, Eggshell thickness	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
438	447: Reduction, Cholesterol transport in mitochondria	413: Reduction, Testosterone synthesis in Leydig cells	Nov 29, 2016	Dec 2, 2016	2 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents
3517	447: Reduction, Cholesterol transport in mitochondria	2319: Decreased, Pregnenolone levels	Apr 8, 2025	Apr 8, 2025	None
94	78: Reduction, Cumulative fecundity and spawning	360: Decrease, Population growth rate	Nov 29, 2016	Mar 20, 2017	12 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2142	78: Reduction, Cumulative fecundity and spawning	361: Decline, Population	May 25, 2020	May 25, 2020	None
2924	78: Reduction, Cumulative fecundity and spawning	442: Decreased, Population trajectory	May 22, 2023	May 22, 2023	2 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3228	1610: Reduction, DHEA	1690: Decrease, circulating testosterone levels	May 24, 2024	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
123	106: Reduction, Eggshell thickness	253: N/A, Reproductive failure	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
460	446: Reduction of testosterone	414: Increase, Luteinizing hormone (LH)	Nov 29, 2016	Dec 3, 2016	None
608	446: Reduction of testosterone	348: Malformation, Male reproductive tract	Nov 29, 2016	Dec 2, 2016	None
1649	446: Reduction of testosterone	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Aug 11, 2017	Aug 11, 2017	None
143	129: Reduction, Gonadotropins, circulating concentrations	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
667	64: Reduction, Ionotropic GABA receptor chloride channel conductance	669: Reduction, Neuronal synaptic inhibition	Nov 29, 2016	Apr 29, 2019	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
683	669: Reduction, Neuronal synaptic inhibition	682: Generation, Amplified excitatory postsynaptic potential (EPSP)	Nov 29, 2016	May 15, 2018	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
1018	981: Reduction, NFAT/AP-1 complex formation	982: Suppression, Suppression in mixed lymphocyte reaction (MLR)	Nov 29, 2016	Dec 3, 2016	None
1019	981: Reduction, NFAT/AP-1 complex formation	983: Suppression, Suppression of T-cell dependent antibody response (TDAR)	Nov 29, 2016	Dec 3, 2016	None
1020	981: Reduction, NFAT/AP-1 complex formation	984: Impairment, T-cell dependent antibody response	Nov 29, 2016	Dec 3, 2016	None
1021	981: Reduction, NFAT/AP-1 complex formation	985: Relief, Relief of atopic dermatitis	Nov 29, 2016	Dec 3, 2016	None
1022	981: Reduction, NFAT/AP-1 complex formation	986: Impairment of TDAR	Nov 29, 2016	Dec 3, 2016	None
1256	981: Reduction, NFAT/AP-1 complex formation	1203: Suppression, Suppression of production of cytotoxic T-cells	Nov 29, 2016	Dec 3, 2016	None

Key Event Relationships (KERs)

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