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Showing 1426 to 1450 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2890	55: Cell injury/death	1494: Leukocyte recruitment/activation	Apr 13, 2023	Apr 13, 2023	None
3197	55: Cell injury/death	1931: Disruption of the intestinal barrier	Apr 17, 2024	Apr 17, 2024	1 AOP 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
3198	55: Cell injury/death	177: Increase, Mitochondrial dysfunction	Apr 17, 2024	Apr 17, 2024	None
3244	55: Cell injury/death	2084: Increase, Cardiac remodelling	Jun 4, 2024	Jun 4, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
3245	55: Cell injury/death	1532: Decrease, Cardiac contractility	Jun 4, 2024	Jun 4, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
1746	1527: Increase, Cell membrane depolarization	1526: Increase, Opening of voltage-dependent calcium channel	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
2708	1527: Increase, Cell membrane depolarization	389: Increased, Intracellular Calcium overload	Jul 25, 2022	Jul 25, 2022	None
2788	1527: Increase, Cell membrane depolarization	55: Cell injury/death	Oct 19, 2022	Oct 19, 2022	1 AOP 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
3039	1527: Increase, Cell membrane depolarization	2187: Opening VGCCs	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
890	870: Increase, Cell Proliferation	376: Increased, Induced Mutations in Critical Genes	Nov 29, 2016	Dec 3, 2016	None
893	870: Increase, Cell Proliferation	876: Increase, Mutations in Critical Genes	Nov 29, 2016	Dec 3, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
895	870: Increase, Cell Proliferation	872: Increase, Site of Contact Nasal Tumors	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
1967	870: Increase, Cell Proliferation	1670: Lung cancer	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1980	870: Increase, Cell Proliferation	1556: Increase, lung cancer	Aug 29, 2019	Jan 10, 2023	1 AOP 272: Deposition of energy leading to lung cancer
2419	870: Increase, Cell Proliferation	1090: Increased, mesotheliomas	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
2819	870: Increase, Cell Proliferation	2083: Cataracts	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
3750	870: Increase, Cell Proliferation	1395: Liver Cancer	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1247	1182: Increase, Cell Proliferation (Epithelial Cells)	1192: Increased, Ductal Hyperplasia	Nov 29, 2016	Dec 3, 2016	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1907	1182: Increase, Cell Proliferation (Epithelial Cells)	185: Increase, Mutations	May 8, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
773	716: Increase, cell proliferation (hepatocytes)	774: Increase, Preneoplastic foci (hepatocytes)	Nov 29, 2016	Feb 14, 2017	2 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
1239	716: Increase, cell proliferation (hepatocytes)	1171: Increase, Clonal Expansion of Altered Hepatic Foci	Nov 29, 2016	Dec 3, 2016	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
2254	716: Increase, cell proliferation (hepatocytes)	719: Increase, hepatocellular adenomas and carcinomas	Dec 31, 2020	Dec 31, 2020	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1979	1636: Increase, Chromosomal aberrations	870: Increase, Cell Proliferation	Aug 29, 2019	Mar 8, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1985	1636: Increase, Chromosomal aberrations	1556: Increase, lung cancer	Aug 29, 2019	Jan 10, 2023	1 AOP 272: Deposition of energy leading to lung cancer
637	621: Increase, cilia movement	622: Increased, locomotion	Nov 29, 2016	Dec 3, 2016	None

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