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Showing 51 to 75 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1589	1438: Increased transcription of genes encoding acute phase proteins	1439: Systemic acute phase response	Jun 29, 2017	Jan 17, 2025	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
2542	1963: Torsades de Pointes	1964: Sudden cardiac death	Dec 13, 2021	Dec 13, 2021	1 AOP 433: hERG channel blockade leading to sudden cardiac death
2852	1963: Torsades de Pointes	351: Increased Mortality	Jan 29, 2023	Jan 29, 2023	None
3408	1963: Torsades de Pointes	2281: uncoordinated cardiac contraction	Nov 20, 2024	Nov 20, 2024	1 AOP 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
2148	1792: TLR4 activation	1292: Activation, JNK	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
2155	1792: TLR4 activation	1283: Activation, TGF-beta pathway	Jul 9, 2020	Jul 9, 2020	None
2251	1792: TLR4 activation	1793: AP-1 activation	Dec 23, 2020	Dec 23, 2020	None
2303	1848: TLR Activation/Dysregulation	1496: Increased proinflammatory mediators	Mar 29, 2021	Feb 7, 2023	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
1763	1492: Tissue resident cell activation	1493: Increased pro-inflammatory mediators	Aug 2, 2018	Aug 2, 2018	3 AOPs 38: Protein Alkylation leading to Liver Fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
2834	1492: Tissue resident cell activation	2097: Increase, Pro-Inflammatory Mediators	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
444	280: T4 in neuronal tissue, Decreased	381: BDNF, Reduced	Nov 29, 2016	Apr 4, 2019	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
746	280: T4 in neuronal tissue, Decreased	756: Hippocampal gene expression, Altered	Nov 29, 2016	Aug 11, 2018	5 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
309	279: Thyroperoxidase, Inhibition	277: TH synthesis, Decreased	Nov 29, 2016	Nov 4, 2022	8 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
366	279: Thyroperoxidase, Inhibition	281: T4 in serum, Decreased	Nov 29, 2016	Nov 18, 2025	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
383	279: Thyroperoxidase, Inhibition	402: Cognitive function, decreased	Nov 29, 2016	Dec 3, 2016	None
790	279: Thyroperoxidase, Inhibition	788: Decrease, Incorporation of active iodide into iodotyrosines	Nov 29, 2016	Dec 3, 2016	None
1040	279: Thyroperoxidase, Inhibition	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Feb 22, 2019	None
305	277: TH synthesis, Decreased	281: T4 in serum, Decreased	Nov 29, 2016	Oct 10, 2022	18 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 128: Kidney dysfunction by decreased thyroid hormone 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
810	277: TH synthesis, Decreased	813: Increased, Serum creatinine	Nov 29, 2016	Dec 3, 2016	1 AOP 128: Kidney dysfunction by decreased thyroid hormone
1504	277: TH synthesis, Decreased	381: BDNF, Reduced	May 10, 2017	Apr 4, 2019	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1505	277: TH synthesis, Decreased	851: GABAergic interneurons, Decreased	May 10, 2017	May 29, 2018	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1506	277: TH synthesis, Decreased	341: Impairment, Learning and memory	May 10, 2017	Apr 27, 2026	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1768	277: TH synthesis, Decreased	219: Reduction, Plasma 17beta-estradiol concentrations	Sep 18, 2018	Sep 18, 2018	1 AOP 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish
1636	1462: Thiol protein adducts	1463: Inhibition of lysyl oxidase	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
3295	2240: The NO synthase pathway activation	1928: increased，Vascular endothelial dysfunction	Jul 9, 2024	Jul 9, 2024	1 AOP 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways

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