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All KERs

Showing 1026 to 1050 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2869	1350: Increased, glutamate	2124: increased, Bax	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1522	1396: Increased, glucocorticoid receptor activity	1335: Reduced, BDNF	May 31, 2017	May 31, 2017	2 AOPs 221: Mental stress to depression 222: Mental stress to agitation
2247	959: Increased, Free serum thyroxine (T4)	1158: Increased, Hepatic thyroid hormone uptake/transport	Dec 9, 2020	Dec 9, 2020	2 AOPs 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2268	959: Increased, Free serum thyroxine (T4)	960: Increased, Uptake of thyroxine into tissue	Jan 26, 2021	Jan 26, 2021	None
2272	959: Increased, Free serum thyroxine (T4)	961: Increased, Clearance of thyroxine from serum	Jan 26, 2021	Jan 26, 2021	1 AOP 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
1176	624: Increased, foot detachment	1143: Depletion, energy reserves	Nov 29, 2016	Dec 3, 2016	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1183	624: Increased, foot detachment	623: Increase, predation	Nov 29, 2016	Dec 3, 2016	None
1707	1500: Increased cellular proliferation and differentiation	1501: Increase, ECM deposition	Jan 5, 2018	Dec 7, 2021	None
2652	1500: Increased cellular proliferation and differentiation	68: Increase, Collagen accumulation	May 4, 2022	May 18, 2023	1 AOP 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
2263	460: Increased, Fatty acid uptake	459: Increase, Liver steatosis	Jan 15, 2021	Jan 15, 2021	None
504	465: Increased, FA Influx	291: Accumulation, Triglyceride	Nov 29, 2016	Dec 3, 2016	None
505	465: Increased, FA Influx	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	3 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1658	465: Increased, FA Influx	454: Increased, Triglyceride formation	Aug 31, 2017	Aug 31, 2017	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
3744	465: Increased, FA Influx	459: Increase, Liver steatosis	Feb 24, 2026	Feb 24, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
1521	1320: Increased, extracellular serotonin	1347: Decreased, extracellular serotonin	May 30, 2017	May 30, 2017	None
1529	1320: Increased, extracellular serotonin	1401: Decreased, 5-HT3	Jun 1, 2017	Jun 1, 2017	1 AOP 223: Serotonin transporter activation to seizure
1531	1320: Increased, extracellular serotonin	1336: Activation, 5-HT2A	Jun 2, 2017	Jun 2, 2017	1 AOP 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
3475	1320: Increased, extracellular serotonin	2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors	Jan 14, 2025	Feb 20, 2025	1 AOP 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
3489	1320: Increased, extracellular serotonin	1016: Inhibition, Feeding	Feb 20, 2025	Feb 20, 2025	1 AOP 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
3104	2199: Increased, Expression of LXR activated genes	89: Synthesis, De Novo Fatty Acid (FA)	Dec 7, 2023	Mar 29, 2024	1 AOP 518: Liver X Receptor (LXR) activation leads to liver steatosis
2583	1973: Increased, estrogens	1076: Increased, circulating estrogen levels	Feb 26, 2022	Mar 1, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
2737	748: Increased, Estrogen receptor (ER) activity	2046: Increase, Vitellogenin mRNA	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
3717	2402: Increased, E2 production in ovaries	2294: Plasma E2, increased	Jan 29, 2026	Feb 3, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3115	2205: Increased, essential element imbalance	1115: Increase, ROS	Jan 24, 2024	Aug 2, 2024	1 AOP 521: Essential element imbalance leads to reproductive failure via oxidative stress
1251	1188: Increased, ER binding to T.F. to DNA (non-classical pathway)	1182: Increase, Cell Proliferation (Epithelial Cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer

Key Event Relationships (KERs)

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