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All KERs

Showing 1501 to 1525 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3591	2347: Increase, Lipid degradation	459: Increase, Liver steatosis	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3830	2446: lipid accumulation	786: Increase, Cytotoxicity (hepatocytes)	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3854	2446: lipid accumulation	459: Increase, Liver steatosis	Sep 9, 2026	Sep 9, 2026	1 AOP 653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
3855	2446: lipid accumulation	2454: small intestine steatosis	Sep 9, 2026	Sep 9, 2026	1 AOP 653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
1477	1378: Increase, leukocyte adherence	1379: Activate, leukocyte	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
146	134: Increase, Kupffer cell activation	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
147	134: Increase, Kupffer cell activation	276: Up Regulation, TGFbeta1 expression	Nov 29, 2016	Nov 29, 2016	None
3726	134: Increase, Kupffer cell activation	1489: Increase, Steatohepatitis	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1441	1339: Increase, intracellular calcium	1340: Activate, calmodulin	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
2954	1339: Increase, intracellular calcium	2151: Disruption, neurotransmitter release	Jun 27, 2023	Apr 11, 2024	1 AOP 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release
2968	1339: Increase, intracellular calcium	1262: Apoptosis	Jul 18, 2023	Apr 11, 2024	1 AOP 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
3140	1339: Increase, intracellular calcium	177: Increase, Mitochondrial dysfunction	Mar 6, 2024	Apr 11, 2024	1 AOP 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
3178	2119: Increase, Insulin resistance	2129: Metabolically unhealthy Obesity	Apr 9, 2024	Apr 9, 2024	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
3180	2119: Increase, Insulin resistance	2145: Metabolic syndrome	Apr 9, 2024	Apr 9, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
3721	2119: Increase, Insulin resistance	2408: Increase, Adipose lipolysis	Feb 10, 2026	Feb 10, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
1390	1296: Increase, insulin	1297: Activation, insulin receptor	Apr 12, 2017	Apr 12, 2017	None
1440	1338: Increase, inositol triphosphate	1339: Increase, intracellular calcium	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
778	777: Increase, Inflammation (corneal cells)	778: Increase, Regenerative cell proliferation (corneal cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
781	149: Increase, Inflammation	781: Increase, Regenerative cell proliferation (forestomach epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
929	149: Increase, Inflammation	357: Cholestasis, Pathology	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
1722	149: Increase, Inflammation	1273: Expression of Collagen	Mar 18, 2018	Mar 18, 2018	None
1724	149: Increase, Inflammation	1457: EMT	Mar 18, 2018	Jan 30, 2019	2 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans
1839	149: Increase, Inflammation	1587: Fibroproliferative airway lesions	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
2573	149: Increase, Inflammation	1196: Increased, Invasion	Feb 15, 2022	Mar 5, 2024	1 AOP 439: Activation of the AhR leading to metastatic breast cancer
2574	149: Increase, Inflammation	1376: Increase, angiogenesis	Feb 15, 2022	Dec 20, 2022	1 AOP 439: Activation of the AhR leading to metastatic breast cancer

Key Event Relationships (KERs)

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