Key Event Relationships (KERs)

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Showing 2576 to 2600 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
136 119: N/A, Gap 49: Reduction, Ca and HCO3 transport to shell gland Nov 29, 2016 Dec 3, 2016
996 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects 854: Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Dec 2, 2016
593 590: N/A, hypoxia 591: Increased, amputations Nov 29, 2016 Dec 3, 2016
3307 590: N/A, hypoxia 1376: Increase, angiogenesis Jul 18, 2024 Jul 18, 2024 None
3370 590: N/A, hypoxia 885: Increase, Cancer Oct 25, 2024 Oct 25, 2024
168 158: N/A, Interferences with SH-/selen-proteins 130: Depletion, GSH Nov 29, 2016 Dec 3, 2016 None
2889 345: N/A, Liver Steatosis 55: Cell injury/death Apr 13, 2023 Apr 13, 2023 None
182 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number 321: N/A, Cyanosis occurs Nov 29, 2016 Dec 3, 2016
207 352: N/A, Neurodegeneration 188: Neuroinflammation Nov 29, 2016 Jun 13, 2018
368 352: N/A, Neurodegeneration 386: Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016 None
647 352: N/A, Neurodegeneration 618: Decreased, Neuronal network function in adult brain Nov 29, 2016 Nov 29, 2016
1069 352: N/A, Neurodegeneration 341: Impairment, Learning and memory Nov 29, 2016 Apr 11, 2024
2287 352: N/A, Neurodegeneration 1841: Encephalitis Feb 23, 2021 Feb 23, 2021
3070 352: N/A, Neurodegeneration 388: Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023
3075 352: N/A, Neurodegeneration 637: impaired, Learning and memory Oct 17, 2023 Oct 17, 2023
3081 352: N/A, Neurodegeneration 1348: Increase, seizure Oct 17, 2023 Oct 17, 2023
242 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin 21: Altered regulation, Alpha hemoglobin Nov 29, 2016 Dec 3, 2016
243 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin 118: Formation, Formation of hemoglobin adducts Nov 29, 2016 Dec 3, 2016
245 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin 250: Damaging, Red blood cells; hemolysis Nov 29, 2016 Dec 3, 2016
3323 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin 1392: Increase, Oxidative Stress Jul 24, 2024 Jul 24, 2024
650 634: N/A, sedation 635: Decreased, locomotion Nov 29, 2016 Dec 3, 2016
324 294: N/A, Unknown 57: Proliferation, Cell proliferation in the absence of cytotoxicity Nov 29, 2016 Dec 3, 2016
751 294: N/A, Unknown 759: Increased, Kidney Failure Nov 29, 2016 Dec 3, 2016
3148 1259: narcosis 177: Increase, Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
3754 1263: Necrosis 2009: Activation, inflammation pathway Mar 25, 2026 Mar 25, 2026