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Showing 1651 to 1675 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3724	459: Increase, Liver steatosis	2405: Increase, Hepatocellular lipotoxicity	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
461	414: Increase, Luteinizing hormone (LH)	416: Increase proliferation, Leydig cell	Nov 29, 2016	Dec 3, 2016	1 AOP 51: PPARα activation leading to impaired fertility in adult male rodents
3461	2302: Increase, Malformations	351: Increased Mortality	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3641	2373: Increase, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
2119	1785: Increase, Mitochondrial ATP synthase antagonism	1477: OXPHOS, decreased	May 8, 2020	May 8, 2020	None
2229	1785: Increase, Mitochondrial ATP synthase antagonism	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
2183	1811: Increase, Complex III dysfunction	1812: Increase, Cyt c release	Nov 2, 2020	Nov 2, 2020	None
363	177: Increase, Mitochondrial dysfunction	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	4 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction
582	177: Increase, Mitochondrial dysfunction	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
660	177: Increase, Mitochondrial dysfunction	664: Overwhelmed, Mitochondrial DNA repair mechanisms	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
664	177: Increase, Mitochondrial dysfunction	583: impaired, Thoracic shivering	Nov 29, 2016	Dec 3, 2016	None
904	177: Increase, Mitochondrial dysfunction	889: Proteostasis, impaired	Nov 29, 2016	Oct 3, 2025	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 273: Mitochondrial complex inhibition leading to liver injury
908	177: Increase, Mitochondrial dysfunction	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Oct 3, 2025	4 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
1152	177: Increase, Mitochondrial dysfunction	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	1 AOP 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
1154	177: Increase, Mitochondrial dysfunction	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
1311	177: Increase, Mitochondrial dysfunction	1243: Altered, Ca2+-calmodulin activated signal transduction	Nov 29, 2016	Dec 3, 2016	2 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
1684	177: Increase, Mitochondrial dysfunction	1392: Increase, Oxidative Stress	Nov 9, 2017	Nov 9, 2017	2 AOPs 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2228	177: Increase, Mitochondrial dysfunction	1771: Decrease, ATP pool	Dec 4, 2020	Dec 4, 2020	None
2822	177: Increase, Mitochondrial dysfunction	40: Mitochondrial ATP production, decreased	Jan 5, 2023	Jan 5, 2023	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 258: Renal protein alkylation leading to kidney toxicity
3131	177: Increase, Mitochondrial dysfunction	1365: Increase, Apoptosis	Feb 21, 2024	Feb 21, 2024	2 AOPs 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3132	177: Increase, Mitochondrial dysfunction	1928: increased，Vascular endothelial dysfunction	Feb 21, 2024	Feb 21, 2024	2 AOPs 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3134	177: Increase, Mitochondrial dysfunction	709: Increase, Cytotoxicity (renal tubular cell)	Feb 28, 2024	Mar 6, 2024	2 AOPs 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
3136	177: Increase, Mitochondrial dysfunction	1585: Proteasomal dysfunction	Feb 29, 2024	Feb 29, 2024	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3141	177: Increase, Mitochondrial dysfunction	1115: Increase, ROS	Mar 6, 2024	Apr 11, 2024	3 AOPs 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 273: Mitochondrial complex inhibition leading to liver injury 472: DNA adduct formation leading to kidney failure
3146	177: Increase, Mitochondrial dysfunction	1262: Apoptosis	Mar 13, 2024	Mar 13, 2024	3 AOPs 205: AOP from chemical insult to cell death 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 595: Emerging OPFRS reproductive outcome pathway

Key Event Relationships (KERs)

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