Key Event Relationships (KERs)

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Showing 2226 to 2250 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1186 620: Increased, serotonin (5-HT) 1 1145: Decreased, gametogenesis Nov 29, 2016 Dec 3, 2016 None
1189 620: Increased, serotonin (5-HT) 1 622: Increased, locomotion Nov 29, 2016 Dec 3, 2016 None
1192 620: Increased, serotonin (5-HT) 1 1147: increased or inappropriate, mantel display Nov 29, 2016 Dec 3, 2016 None
1524 1397: Increased, serotonin transporter activity 1398: Increased, intracellular serotonin Jun 1, 2017 Jun 1, 2017
1528 1397: Increased, serotonin transporter activity 1347: Decreased, extracellular serotonin Jun 1, 2017 Jun 1, 2017
813 813: Increased, Serum creatinine 818: Occurrence, Cytoplasmic vacuolization (Renal tubule) Nov 29, 2016 Dec 3, 2016
814 813: Increased, Serum creatinine 823: Occurrence, Cystic dilatation (renal tubule) Nov 29, 2016 Dec 3, 2016
816 813: Increased, Serum creatinine 824: Occurrence, Cytoplasmic vacuolization (podocyte) Nov 29, 2016 Dec 3, 2016
2582 1972: Increased, Steroidogenic acute regulatory protein (StAR) 1973: Increased, estrogens Feb 26, 2022 Mar 1, 2022
3367 2269: Increased, SREBP2 protein expression 2270: Increased, cholesterol synthesis enzymes Oct 22, 2024 Feb 10, 2025
3388 2269: Increased, SREBP2 protein expression 2276: Increased, PCSK9 protein expression Nov 13, 2024 Feb 13, 2025
3476 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors 1016: Inhibition, Feeding Jan 14, 2025 Feb 20, 2025
296 366: Increased, Structural malformations 342: Increased, Lethality Nov 29, 2016 Dec 3, 2016 None
1527 1400: Increased, synaptic release 1320: Increased, extracellular serotonin Jun 1, 2017 Jun 1, 2017
1064 1021: Increased, T4/T3 catabolism 1022: Decreased, serum T4/T3 Nov 29, 2016 Dec 3, 2016 None
2423 1021: Increased, T4/T3 catabolism 281: T4 in serum, Decreased Jul 7, 2021 Jul 7, 2021 None
1066 1023: Increased, Thyroid-stimulating hormone (TSH) 1024: Increased, Hypertrophy and proliferation (follicular cell) Nov 29, 2016 Dec 3, 2016 None
2240 1023: Increased, Thyroid-stimulating hormone (TSH) 1828: Increased, Thyroxine (T4) in serum Dec 9, 2020 Dec 9, 2020
2424 1023: Increased, Thyroid-stimulating hormone (TSH) 739: Increase, Hypertrophy and proliferation (follicular cell) Jul 7, 2021 Jul 7, 2021
2425 1023: Increased, Thyroid-stimulating hormone (TSH) 753: Increase, Thyroid-stimulating hormone (TSH) Jul 7, 2021 Jul 7, 2021 None
2241 1828: Increased, Thyroxine (T4) in serum 1101: Altered, Amphibian metamorphosis Dec 9, 2020 Dec 9, 2020
2242 1828: Increased, Thyroxine (T4) in serum 1829: Altered, TH-dependent gene expression Dec 9, 2020 Dec 9, 2020
486 454: Increased, Triglyceride formation 459: Increase, Liver steatosis Nov 29, 2016 Dec 3, 2016
1201 1154: Increased, Triiodothyronine (T3) in tissues 1101: Altered, Amphibian metamorphosis Nov 29, 2016 Dec 3, 2016 None
2243 1154: Increased, Triiodothyronine (T3) in tissues 1829: Altered, TH-dependent gene expression Dec 9, 2020 Dec 9, 2020