AOP-Wiki

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All Key Events

Showing 451 to 475 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1966	Decrease, Asexual reproduction Short Name Decrease, Asexual reproduction	0	Individual	Jan 17, 2022	Jan 17, 2022	None
1965	Increase, Pollen abnormal Short Name Increase, Pollen abnormal	0	Organ	Jan 13, 2022	Jan 13, 2022	435: Deposition of ionising energy leads to population decline via pollen abnormal
1964	Sudden cardiac death Short Name Sudden cardiac death	0	Individual	Dec 13, 2021	Dec 13, 2021	433: hERG channel blockade leading to sudden cardiac death
1963	Torsades de Pointes Short Name Torsades de Pointes	0	Organ	Dec 13, 2021	Jan 29, 2023	2 AOPs 433: hERG channel blockade leading to sudden cardiac death 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1962	Prolongation of QT interval Short Name Prolongation of QT interval	0	Organ	Dec 13, 2021	Dec 13, 2021	3 AOPs 433: hERG channel blockade leading to sudden cardiac death 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
1961	Prolongation of Action Potential Duration Short Name Prolongation of Action Potential	0	Organ	Dec 13, 2021	Jan 29, 2023	3 AOPs 433: hERG channel blockade leading to sudden cardiac death 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
1960	Inhibition of Ikr Short Name Inhibition of Ikr	0	Tissue	Dec 13, 2021	Dec 13, 2021	None
1959	Induction of hERG trafficking defects Short Name Induction of hERG trafficking defects	0	Cellular	Dec 13, 2021	Dec 13, 2021	None
1958	Direct hERG channel blockage Short Name Direct hERG channel blockage	0	Cellular	Dec 13, 2021	Dec 13, 2021	None
1957	hERG channel biogenesis interference Short Name hERG channel biogenesis interference	0	Molecular	Dec 13, 2021	Dec 13, 2021	None
1956	Binding to hERG channel Short Name Binding to hERG channel	0	Molecular	Dec 13, 2021	Dec 13, 2021	None
1955	Acute Myeloid Leukemia Short Name AML	0	Individual	Dec 3, 2021	Dec 3, 2021	432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
1954	Gut microbiota, alteration Short Name Gut dysbiosis	0	Organ	Nov 30, 2021	Jan 4, 2022	428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
1953	Gestational diabetes mellitus Short Name GDM	0	Individual	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1952	Abnormal, Glucose homeostasis Short Name Abnormal, Glucose homeostasis	0	Organ	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1951	Decrease, Glucose uptake Short Name Decrease, Glucose uptake	0	Cellular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1950	Increase, TNF Short Name Increase, TNF	0	Molecular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1949	Decrease, GLUT4 Short Name Decrease, GLUT4	0	Cellular	Nov 18, 2021	Nov 18, 2021	431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1948	Increased ACE2 expression Short Name Upregulation of ACE2	0	Molecular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1947	Pericyte dysfunction Short Name Pericyte dysfunction	0	Cellular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1946	Impaired mechanotransduction of pericytes Short Name	0	Cellular	Oct 28, 2021	Oct 28, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1945	Dysfunctional Autophagy Short Name Dysfunctional autophagy	0	Cellular	Oct 26, 2021	Oct 26, 2021	2 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 452: Adverse outcome pathway of PM-induced respiratory toxicity
1944	Synaptic dysfunction Short Name Dysfunctional synapses	2	Organ	Oct 26, 2021	Aug 4, 2025	3 AOPs 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
1943	Hyperphosphorylation of Tau Short Name p-Tau	0	Cellular	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1942	Accumulation, Cytosolic toxic Tau oligomers Short Name Accumulation, Toxic Tau oligomers	0	Cellular	Oct 26, 2021	Oct 26, 2021	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants