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All Key Events

Showing 1301 to 1325 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1060	Alteration, lipid metabolism Short Name Alteration, lipid metabolism	1	Cellular	Nov 29, 2016	Oct 30, 2023	2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1059	Increased, cholestasis Short Name Increased, cholestasis	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1058	Decreased, bile flow Short Name Decreased, bile flow	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1057	Increased, PPAR-alpha activation Short Name Increased, PPAR-alpha activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1056	Decrease, E2 blood concentrations at hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
1054	Promotion, ovarian granular cell tumors Short Name Promotion, ovarian granular cell tumors	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1053	Promotion, ovarian adenomas Short Name Promotion, ovarian adenomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1052	Hyperplasia, ovarian epithelium Short Name Hyperplasia, ovarian epithelium	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1051	Hyperplasia, ovarian stromal cells Short Name Hyperplasia, ovarian stromal cells	1	Cellular	Nov 29, 2016	Sep 16, 2017	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1050	Increased, secretion of LH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1049	Increased, secrection of FSH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1048	Increased, secretion of leutenizing hormone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1047	Increased, secretion of GnRH from hypothalamus Short Name	1	Cellular	Nov 29, 2016	Apr 6, 2026	6 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
1046	Suppression, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Feb 28, 2022	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1045	Decreased, Ovarian E2 Short Name Decreased, Ovarian E2	1	Tissue	Nov 29, 2016	Sep 16, 2017	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1044	Promotion, mesovarian leiomyomas Short Name Promotion, mesovarian leiomyomas	1	Tissue	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1043	Hypertrophy/hyperplasia, smooth muscle Short Name Hypertrophy/hyperplasia, smooth muscle	1	Cellular	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1042	Proliferation/Clonal Expansion, smooth muscle Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1041	Proliferation, smooth muscle Short Name Proliferation, smooth muscle	0		Nov 29, 2016	Nov 29, 2016	None
1040	relaxation, smooth muscle Short Name relaxation, smooth muscle	1	Tissue	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1039	Increased activity, beta-2 adrenergic receptor Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse 557: β2-Receptor agonist leading to Cardiomyopathy
1038	Activation, beta-2 adrenergic receptor Short Name Activation, beta-2 adrenergic receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse 554: β-adrenergic receptor agonists leading to arrhythmias.
1037	Increased, hemagiosarcoma Short Name Increased, hemagiosarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1036	Increased, liposarcoma Short Name Increased, liposarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1035	Increased, Firbrosarcoma Short Name Increased, Firbrosarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters