AOP-Wiki

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All Key Events

Showing 1851 to 1875 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

173	N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
169	Disruption, Membrane integrity Short Name Disruption, Membrane integrity	1	Cellular	Nov 29, 2016	Sep 16, 2017	35: Narcosis leading to respiratory failure
168	Decreased, Lymphocytes Short Name Decreased, Lymphocytes	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
167	Activation, LXR Short Name Activation, LXR	2	Molecular	Nov 29, 2016	May 21, 2024	3 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
166	Decreased, Long-term potentiation (LTP) Short Name Decreased, Long-term potentiation (LTP)	1	Organ	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
165	Activation, Long term AHR receptor driven direct and indirect gene expression changes Short Name	1	Cellular	Nov 29, 2016	Dec 2, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
164	Induction, Liver “Dysfunctional” Changes by CGA 330050 Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
161	Increase, Liver and splenic hemosiderosis Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
158	N/A, Interferences with SH-/selen-proteins Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
155	Inadequate DNA repair Short Name Inadequate DNA repair	1	Cellular	Nov 29, 2016	Mar 8, 2024	11 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 322: Alkylation of DNA leading to reduced sperm count 397: Bulky DNA adducts leading to mutations 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 443: DNA damage and mutations leading to Metastatic Breast Cancer 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
152	Suppression, Inflammatory cytokines Short Name Suppression, Inflammatory cytokines	1	Individual	Nov 29, 2016	Dec 3, 2016	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
151	Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Short Name	2	Molecular	Nov 29, 2016	Nov 5, 2020	None
149	Increase, Inflammation Short Name Increase, Inflammation	1	Cellular	Nov 29, 2016	Feb 28, 2024	9 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans 439: Activation of the AhR leading to metastatic breast cancer 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 577: AhR activation leading to endometriosis 472: DNA adduct formation leading to kidney failure
147	Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
145	Induction, IKB inhibitory protein Short Name Induction, IKB inhibitory protein	1	Cellular	Nov 29, 2016	Sep 16, 2017	14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
142	Hyperplasia, Hyperplasia Short Name Hyperplasia, Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
140	Decreased, HSD17B10 expression Short Name Decreased, HSD17B10 expression	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
139	N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Short Name	1	Tissue	Nov 29, 2016	Nov 29, 2016	41: Sustained AhR Activation leading to Rodent Liver Tumours
134	Increase, Kupffer cell activation Short Name Increase, Kupffer cell activation	1	Cellular	Nov 29, 2016	Feb 11, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
131	Down Regulation, Gulcose-6-phosphate dehydrogenase Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
130	Depletion, GSH Short Name Depletion, GSH	1	Cellular	Nov 29, 2016	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
129	Reduction, Gonadotropins, circulating concentrations Short Name	2	Organ	Nov 29, 2016	May 9, 2018	23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
122	Increase, Glucocorticoid receptor activation Short Name Increase, GR activation	1	Molecular	Nov 29, 2016	Feb 12, 2026	11 AOPs 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility 214: Network of SSRIs (selective serotonin reuptake inhibitors) 318: Glucocorticoid Receptor activation leading to hepatic steatosis 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 581: Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
119	N/A, Gap Short Name N/A, Gap	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
118	Formation, Formation of hemoglobin adducts Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity