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Showing 1401 to 1425 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2467	1825: Increase, Cell death	1930: Altered, inner ear development	Aug 23, 2021	Aug 29, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
2489	1825: Increase, Cell death	1931: Disruption of the intestinal barrier	Oct 19, 2021	Oct 19, 2021	None
2706	1825: Increase, Cell death	896: Parkinsonian motor deficits	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2718	1825: Increase, Cell death	188: Neuroinflammation	Jul 25, 2022	Jul 25, 2022	None
2760	1825: Increase, Cell death	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2842	1825: Increase, Cell death	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Nov 6, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2863	1825: Increase, Cell death	758: Hippocampal Physiology, Altered	Apr 3, 2023	Apr 3, 2023	None
3504	1825: Increase, Cell death	2312: Increased, nasal lesions	Mar 5, 2025	Mar 19, 2025	1 AOP 368: Cytochrome oxidase inhibition leading to increased nasal lesions
3507	1825: Increase, Cell death	2316: Increased, pulmonary edema	Mar 12, 2025	Mar 24, 2025	1 AOP 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema
3508	1825: Increase, Cell death	2317: Loss of olfactory function	Mar 13, 2025	Mar 25, 2025	1 AOP 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
3765	1825: Increase, Cell death	1097: Occurrence, renal proximal tubular necrosis	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
67	55: Cell injury/death	134: Increase, Kupffer cell activation	Nov 29, 2016	Nov 29, 2016	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
68	55: Cell injury/death	265: Increase, HSC activation	Nov 29, 2016	Nov 29, 2016	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 494: AhR activation leading to liver fibrosis
355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
364	55: Cell injury/death	352: N/A, Neurodegeneration	Nov 29, 2016	Sep 10, 2023	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
924	55: Cell injury/death	87: Release, Cytokine	Nov 29, 2016	Nov 9, 2018	None
1688	55: Cell injury/death	386: Neuronal network function, Decreased	Nov 9, 2017	Feb 5, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1718	55: Cell injury/death	1492: Tissue resident cell activation	Feb 1, 2018	Aug 2, 2018	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis
1776	55: Cell injury/death	1493: Increased pro-inflammatory mediators	Nov 12, 2018	Nov 12, 2018	1 AOP 144: Endocytic lysosomal uptake leading to liver fibrosis
1830	55: Cell injury/death	1548: Necrotic Tissue	Jan 7, 2019	Mar 7, 2019	2 AOPs 278: IKK complex inhibition leading to liver injury 273: Mitochondrial complex inhibition leading to liver injury
1831	55: Cell injury/death	1576: Activation, Tissue resident cells (Kuppfer cells)	Jan 7, 2019	Jan 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
1863	55: Cell injury/death	1514: Neurodegeneration	Feb 19, 2019	Feb 19, 2019	None
2767	55: Cell injury/death	1521: Decrease, Growth	Sep 27, 2022	Sep 27, 2022	8 AOPs 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death
2875	55: Cell injury/death	758: Hippocampal Physiology, Altered	Apr 5, 2023	Apr 5, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms

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