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Showing 1826 to 1850 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3294	1392: Increase, Oxidative Stress	2241: Ferroptosis related pathways activation	Jul 9, 2024	Jul 9, 2024	1 AOP 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
3310	1392: Increase, Oxidative Stress	1511: Lipid Peroxidation	Jul 23, 2024	Jul 23, 2024	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
3311	1392: Increase, Oxidative Stress	1512: Unfolded Protein Response	Jul 23, 2024	Jul 23, 2024	1 AOP 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
3312	1392: Increase, Oxidative Stress	352: N/A, Neurodegeneration	Jul 23, 2024	Jul 23, 2024	2 AOPs 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change
3314	1392: Increase, Oxidative Stress	386: Neuronal network function, Decreased	Jul 23, 2024	Jul 23, 2024	1 AOP 501: Excessive iron accumulation leading to neurological disorders
3316	1392: Increase, Oxidative Stress	2244: Altered Stress Response Signaling	Jul 24, 2024	Aug 26, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
3319	1392: Increase, Oxidative Stress	2245: Altered cell differentiation signaling	Jul 24, 2024	Aug 23, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
3322	1392: Increase, Oxidative Stress	618: Decreased, Neuronal network function in adult brain	Jul 24, 2024	Jul 24, 2024	1 AOP 471: Neuron defect induced early behavioral change
3324	1392: Increase, Oxidative Stress	131: Down Regulation, Gulcose-6-phosphate dehydrogenase	Jul 24, 2024	Jul 24, 2024	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3325	1392: Increase, Oxidative Stress	250: Damaging, Red blood cells; hemolysis	Jul 24, 2024	Jul 24, 2024	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3382	1392: Increase, Oxidative Stress	1553: Increase mutations	Nov 6, 2024	Nov 6, 2024	None
3442	1392: Increase, Oxidative Stress	467: Increased, LDL uptake	Nov 25, 2024	Nov 25, 2024	1 AOP 462: Activation of reactive oxygen species leading the atherosclerosis
3602	1392: Increase, Oxidative Stress	1446: Decrease, Coupling of OXPHOS	Aug 21, 2025	Aug 21, 2025	None
3616	1392: Increase, Oxidative Stress	495: Repressed expression of steroidogenic enzymes	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3632	1392: Increase, Oxidative Stress	1767: Increase, Protein oxidation	Sep 8, 2025	Jun 23, 2026	7 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3690	1392: Increase, Oxidative Stress	2363: Mito ROS dysfunction	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3791	1392: Increase, Oxidative Stress	902: Inflammation, Liver	Apr 27, 2026	Apr 27, 2026	2 AOPs 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3808	1392: Increase, Oxidative Stress	2431: Impact on sirtuins-related aging signaling pathway gene expression	Jul 9, 2026	Jul 9, 2026	1 AOP 645: Binding and activation of AhR lead to cardiovascular aging
3811	1392: Increase, Oxidative Stress	2436: Systemic inflammation	Jul 9, 2026	Jul 9, 2026	None
3819	1392: Increase, Oxidative Stress	2440: Hepatic inflammation	Jul 9, 2026	Jul 9, 2026	None
3823	1392: Increase, Oxidative Stress	2443: Hepatocyte injury	Jul 9, 2026	Jul 9, 2026	None
3829	1392: Increase, Oxidative Stress	786: Increase, Cytotoxicity (hepatocytes)	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
1362	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1281: Increased, DNA Damage-Repair	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1364	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1280: Activation, HIF-1	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3166	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	177: Increase, Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans

Key Event Relationships (KERs)

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