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Showing 1851 to 1875 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3513	1115: Increase, ROS	1594: Oxidation of membrane lipids	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3514	1115: Increase, ROS	1595: Oxidation/denatuation of membrane proteins	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3537	1115: Increase, ROS	2195: Increase, CNS Neural cell death	May 22, 2025	May 22, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
3611	1115: Increase, ROS	1862: Decrease, Photosystem II efficiency	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3614	1115: Increase, ROS	112: Antagonism, Estrogen receptor	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3680	1115: Increase, ROS	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3758	1115: Increase, ROS	1967: Pyroptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
779	778: Increase, Regenerative cell proliferation (corneal cells)	779: Increase, Papillomas/carcinomas (squamous cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
782	781: Increase, Regenerative cell proliferation (forestomach epithelial cells)	782: Increase, Hyperplasia (forestomach epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
789	787: Increase, Regenerative cell proliferation (hepatocytes)	774: Increase, Preneoplastic foci (hepatocytes)	Nov 29, 2016	Dec 3, 2016	1 AOP 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
727	734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	735: Increase, Hyperplasia (terminal bronchiolar cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
760	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	767: Increase, Hyperplasia (renal tubular cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
785	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	784: Increase, Hyperplasia (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
797	795: Increase, Regenerative cell proliferation (urothelial cells)	796: Increase, Hyperplasia (urothelial)	Nov 29, 2016	Dec 3, 2016	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
3730	2406: Increase, Regenerative nodule formation	2407: Increase, Cirrhosis	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
280	252: Increase, Renal pathology due to VTG deposition	339: Altered, Larval development	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
3258	252: Increase, Renal pathology due to VTG deposition	351: Increased Mortality	Jun 24, 2024	Jun 24, 2024	1 AOP 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
889	869: Increase, Respiratory or Squamous Metaplasia	870: Increase, Cell Proliferation	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
1930	1652: Increase, SAM depletion	1620: Increase, DNA hypomethylation	May 30, 2019	May 30, 2019	None
1460	1348: Increase, seizure	1363: Increased, epilepsy	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 471: Neuron defect induced early behavioral change
2742	2049: Increase, sex ratio (F/M)	2050: Increase, developmental abnormalities	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2684	2021: Increase, slincR expression	2020: Decrease, sox9 expression	Jun 30, 2022	Sep 8, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2690	2021: Increase, slincR expression	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Sep 8, 2022	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2727	2021: Increase, slincR expression	317: Altered, Cardiovascular development/function	Aug 2, 2022	Sep 8, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
3550	2336: Increase, SREBF1	291: Accumulation, Triglyceride	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index

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