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Showing 726 to 750 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

927	41: Inhibition, Bile Salt Export Pump (ABCB11)	214: Bile accumulation, Pathological condition	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
3395	2277: Inhibition, plasma aromatase activity	219: Reduction, Plasma 17beta-estradiol concentrations	Nov 16, 2024	Nov 16, 2024	1 AOP 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
45	36: Inhibition, Aromatase	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Nov 30, 2016	1 AOP 25: Aromatase inhibition leading to reproductive dysfunction
1767	36: Inhibition, Aromatase	21: Altered regulation, Alpha hemoglobin	Sep 13, 2018	Sep 13, 2018	None
2144	36: Inhibition, Aromatase	1789: Reduction, E2 Synthesis by the undifferentiated gonad	Jun 15, 2020	Jul 11, 2022	1 AOP 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
2167	36: Inhibition, Aromatase	1790: Increased, Differentiation to Testis	Jul 28, 2020	Dec 28, 2022	1 AOP 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
2350	36: Inhibition, Aromatase	1791: Increased, Male Biased Sex Ratio	Apr 13, 2021	Jan 10, 2023	1 AOP 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
3394	36: Inhibition, Aromatase	2277: Inhibition, plasma aromatase activity	Nov 16, 2024	Nov 16, 2024	1 AOP 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3532	36: Inhibition, Aromatase	219: Reduction, Plasma 17beta-estradiol concentrations	Apr 29, 2025	Apr 29, 2025	None
1880	1617: Inhibition, 5α-reductase	1613: Decrease, DHT level	Apr 18, 2019	Mar 20, 2026	4 AOPs 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring
3452	1617: Inhibition, 5α-reductase	1690: Decrease, circulating testosterone levels	Dec 23, 2024	Dec 23, 2024	1 AOP 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
635	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	620: Increased, serotonin (5-HT) 1	Nov 29, 2016	Dec 3, 2016	None
643	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	626: Increased, serotonin (5-HT)	Nov 29, 2016	Dec 3, 2016	5 AOPs 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
1208	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1162: Increased, cilia movement	Nov 29, 2016	Dec 3, 2016	None
1316	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	625: Increased, muscular waves in foot	Jan 13, 2017	Jan 13, 2017	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1317	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1142: Increased, valve movement	Jan 13, 2017	Jan 13, 2017	3 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1318	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	621: Increase, cilia movement	Jan 13, 2017	Jan 13, 2017	3 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1319	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1256: increased mantel display	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1337	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1161: Increased, oocyte maturation	Jan 30, 2017	Jan 30, 2017	1 AOP 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
3474	619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	1320: Increased, extracellular serotonin	Jan 14, 2025	Feb 13, 2025	1 AOP 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
775	766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme	775: Increased, Plasma tyrosine	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
3016	2174: Inhibition VEGF/VEGFR pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
3025	2174: Inhibition VEGF/VEGFR pathway	1928: increased，Vascular endothelial dysfunction	Aug 21, 2023	Aug 21, 2023	1 AOP 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
1891	1627: tyrosinase	1628: Reduction of L-Dopaquinone	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
2974	2155: SULT1E1 inhibition	1973: Increased, estrogens	Jul 28, 2023	Jul 28, 2023	None

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