AOP-Wiki

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Showing 1376 to 1400 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3602	1392: Increase, Oxidative Stress	1446: Decrease, Coupling of OXPHOS	Aug 21, 2025	Aug 21, 2025	3 AOPs 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation
3616	1392: Increase, Oxidative Stress	495: Repressed expression of steroidogenic enzymes	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3632	1392: Increase, Oxidative Stress	1767: Increase, Protein oxidation	Sep 8, 2025	Sep 8, 2025	5 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
3690	1392: Increase, Oxidative Stress	2363: Mito ROS dysfunction	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3791	1392: Increase, Oxidative Stress	902: Inflammation, Liver	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
763	769: Increase, Oxidative metabolism	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
1909	1634: Increase, Oxidative DNA damage	155: Inadequate DNA repair	May 19, 2019	Mar 8, 2024	3 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 478: Deposition of energy leading to occurrence of cataracts 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage
1913	1634: Increase, Oxidative DNA damage	1635: Increase, DNA strand breaks	May 19, 2019	Dec 17, 2024	2 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 478: Deposition of energy leading to occurrence of cataracts
1914	1634: Increase, Oxidative DNA damage	185: Increase, Mutations	May 19, 2019	Jan 9, 2023	1 AOP 296: Oxidative DNA damage leading to chromosomal aberrations and mutations
2591	1634: Increase, Oxidative DNA damage	1444: Increase, Follicular atresia	Mar 1, 2022	Mar 1, 2022	1 AOP 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia
2592	1634: Increase, Oxidative DNA damage	1775: Increase, Oocyte apoptosis	Mar 1, 2022	Mar 1, 2022	1 AOP 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
3230	1634: Increase, Oxidative DNA damage	1461: Increase, DSB	May 27, 2024	May 27, 2024	1 AOP 330: Excessive reactive oxygen species production leading to mortality (4)
3232	1634: Increase, Oxidative DNA damage	1365: Increase, Apoptosis	May 27, 2024	May 27, 2024	None
3359	1634: Increase, Oxidative DNA damage	55: Cell injury/death	Oct 8, 2024	Oct 8, 2024	None
3362	1634: Increase, Oxidative DNA damage	1505: Cell cycle, disrupted	Oct 8, 2024	Oct 8, 2024	None
3570	1634: Increase, Oxidative DNA damage	1262: Apoptosis	Aug 13, 2025	Aug 13, 2025	None
2117	1783: Increase, Ovarian somatic cell apoptosis (F3)	1784: Increase, Ovarian follicle breakdown (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2106	1776: Increase, Ovarian somatic cell apoptosis	1777: Increase, Ovarian follicle breakdown	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
2118	1784: Increase, Ovarian follicle breakdown (F3)	1782: Decrease, Oogenesis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2107	1777: Increase, Ovarian follicle breakdown	1366: Decrease, Oogenesis	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
2560	1777: Increase, Ovarian follicle breakdown	328: Decrease, Fecundity	Feb 4, 2022	Feb 4, 2022	None
1747	1526: Increase, Opening of voltage-dependent calcium channel	1523: Decrease, Cuticular chitin content	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
2113	1780: Increase, Oocyte apoptosis (F3)	1782: Decrease, Oogenesis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 340: DNA methyltransferase inhibition leading to transgenerational effects (1)
2104	1775: Increase, Oocyte apoptosis	1366: Decrease, Oogenesis	Apr 30, 2020	Apr 30, 2020	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3) 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2386	1775: Increase, Oocyte apoptosis	406: decreased, Fertility	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis

Key Event Relationships (KERs)

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