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Showing 926 to 950 of 3102 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1535	1404: Decreased, mucosal blood flow	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1538	1406: Decreased, mucous	1405: Reduced, mucosal defense	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
3663	2105: Decreased, mbp expression in oligodendrocytes	2266: Demyelination, increased	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
634	618: Decreased, Neuronal network function in adult brain	341: Impairment, Learning and memory	Nov 29, 2016	Nov 29, 2016	1 AOP 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
2656	618: Decreased, Neuronal network function in adult brain	1583: Sensory axonal peripheral neuropathy	May 16, 2022	May 16, 2022	1 AOP 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
3072	618: Decreased, Neuronal network function in adult brain	2150: Neurological disorder	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3073	618: Decreased, Neuronal network function in adult brain	188: Neuroinflammation	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3074	618: Decreased, Neuronal network function in adult brain	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Oct 17, 2023	Oct 17, 2023	None
3076	618: Decreased, Neuronal network function in adult brain	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
1448	1330: Decreased, neuroplasticity	1345: Increased, agitation	Apr 14, 2017	Apr 14, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation
1449	1330: Decreased, neuroplasticity	1346: Increased, depression	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 224: Serotonin transporter activation to depression 604: Binding of Alpha 1-Adrenergics to Antagonists Leading to Depression
212	193: Decreased, Nitric Oxide	166: Decreased, Long-term potentiation (LTP)	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
1084	1045: Decreased, Ovarian E2	1047: Increased, secretion of GnRH from hypothalamus	Nov 29, 2016	Dec 3, 2016	None
1085	1045: Decreased, Ovarian E2	1056: Decrease, E2 blood concentrations at hypothalamus	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
2803	2074: Decrease overall oxygen binding capacity (methemocyanin formation)	2076: Increase, hemocyanin mRNA	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1433	1324: Decreased, packaged serotonin	1325: Decreased, synaptic release	Apr 14, 2017	Apr 14, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
503	216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)	327: Accumulation, Fatty acid	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
881	859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	860: Decreased, Mitochondrial Fatty Acid Beta Oxidation	Nov 29, 2016	Nov 29, 2016	None
3289	2237: Decreased, Plasma sodium concentrations	1768: Increase, Abnormal osmoregulation	Jul 8, 2024	Dec 3, 2024	None
3346	2237: Decreased, Plasma sodium concentrations	2261: Decreased, blood plasma volume	Sep 20, 2024	Dec 3, 2024	1 AOP 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
1491	442: Decreased, Population trajectory	351: Increased Mortality	Apr 18, 2017	Apr 18, 2017	None
257	231: Decreased, PPAR-alpha activation	140: Decreased, HSD17B10 expression	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
2042	231: Decreased, PPAR-alpha activation	459: Increase, Liver steatosis	Feb 22, 2020	Feb 22, 2020	None
259	232: Decreased, PPAR-beta activation	140: Decreased, HSD17B10 expression	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
260	233: Decreased, PPAR-gamma activation	140: Decreased, HSD17B10 expression	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis

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