Adverse Outcome Pathways with Reactive Oxygen Species as a MIE

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AOP Collection · Draft · Created by Katarina Živančević (send email)

Purpose
AOPs in which increased reactive oxygen species (ROS) serves as a molecular initiating event (MIE), leading to diverse adverse outcomes following exposure to different chemical, physical, or biological stressors.
Creation Strategy
Manual inspection of AOPs containing increased reactive oxygen species (ROS) as at least one MIE. Search term in the MIE column: *reactive oxygen species
Creation Strategy Notes

AOP 647 (ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response) could not be added to the collection.

AOPs in this Collection (31)

ID Title License OECD Status
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure BY-SA Under Review
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer BY-SA Under Review
324 Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption BY-SA Under Development
325 Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death BY-SA Under Development
326 Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation BY-SA Under Development
327 Excessive reactive oxygen species production leading to mortality (1) BY-SA
328 Excessive reactive oxygen species production leading to mortality (2) BY-SA
329 Excessive reactive oxygen species production leading to mortality (3) BY-SA
330 Excessive reactive oxygen species production leading to mortality (4) BY-SA
331 Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death BY-SA Under Development
332 Increase in reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation BY-SA Under Development
333 Increase in reactive oxygen species leading to growth inhibition via protein oxidation and cell death BY-SA Under Development
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway BY-SA
462 Activation of reactive oxygen species leading the atherosclerosis BY-SA
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity BY-SA
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. BY-SA
488 Increased reactive oxygen species production leading to decreased cognitive function BY-SA
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway BY-SA
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects BY-SA
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway BY-SA
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production BY-SA
595 Emerging OPFRS reproductive outcome pathway BY-SA
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death BY-SA
598 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation BY-SA
599 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death BY-SA
600 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth BY-SA
601 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation BY-SA
602 Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage BY-SA
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption BY-SA
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) All rights reserved
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis BY-SA
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