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All Key Events

Showing 626 to 650 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1782	Decrease, Oogenesis (F3) Short Name Decrease, Oogenesis (F3)	0	Organ	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1781	Decrease, Fecundity (F3) Short Name Decrease, Fecundity (F3)	0	Individual	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1780	Increase, Oocyte apoptosis (F3) Short Name Increase, Oocyte apoptosis (F3)	0	Cellular	Apr 30, 2020	Apr 30, 2020	340: DNA methyltransferase inhibition leading to transgenerational effects (1)
1779	Increase, Caspase transcription (F3) Short Name Increase, Casp transcription (F3)	0	Molecular	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1778	Decrease, Heritable DNA methylation (F3) Short Name	0	Molecular	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1777	Increase, Ovarian follicle breakdown Short Name Increase, Ovarian follicle breakdown	0	Organ	Apr 30, 2020	Apr 30, 2020	2 AOPs 337: DNA methyltransferase inhibition leading to population decline (2) 339: DNA methyltransferase inhibition leading to population decline (4)
1776	Increase, Ovarian somatic cell apoptosis Short Name	0	Cellular	Apr 30, 2020	Apr 30, 2020	2 AOPs 337: DNA methyltransferase inhibition leading to population decline (2) 339: DNA methyltransferase inhibition leading to population decline (4)
1775	Increase, Oocyte apoptosis Short Name Increase, Oocyte apoptosis	0	Cellular	Apr 30, 2020	Apr 30, 2020	5 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3) 396: Deposition of ionizing energy leads to population decline via impaired meiosis 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
1774	Increase, Caspase transcription Short Name Increase, Casp transcription	0	Molecular	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4)
1773	Decrease, Global DNA methylation Short Name Decrease, Global DNA methylation	0	Molecular	Apr 30, 2020	Apr 30, 2020	4 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
1772	Decrease, Triglyceride Short Name Decrease, TAG	0	Cellular	Apr 30, 2020	May 27, 2024	329: Excessive reactive oxygen species production leading to mortality (3)
1771	Decrease, Adenosine triphosphate pool Short Name Decrease, ATP pool	1	Cellular	Apr 30, 2020	Jun 14, 2021	21 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3) 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate
1770	Decrease, Mitochondrial membrane potential Short Name Decrease, MMP	0	Cellular	Apr 30, 2020	Apr 30, 2020	3 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1769	Increase, Body fluid overload Short Name Increase, Body fluid overload	0	Tissue	Apr 30, 2020	Apr 30, 2020	327: Excessive reactive oxygen species production leading to mortality (1)
1768	Increase, Abnormal osmoregulation Short Name Increase, Abnormal osmoregulation	0	Tissue	Apr 30, 2020	Aug 6, 2024	327: Excessive reactive oxygen species production leading to mortality (1)
1767	Increase, Protein oxidation Short Name Increase, Protein oxidation	0	Molecular	Apr 30, 2020	Apr 30, 2020	7 AOPs 327: Excessive reactive oxygen species production leading to mortality (1) 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
1765	Increase, Formation of DNA photoproducts Short Name	0	Molecular	Apr 30, 2020	Apr 30, 2020	None
1763	Urothelial Tumor Short Name carcinogenicity	0	Organ	Apr 21, 2020	Apr 21, 2020	335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
1762	Urothelial cell injury/death Short Name cell injury	0	Cellular	Apr 21, 2020	Apr 21, 2020	335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
1761	Inhibition, Fin regeneration Short Name Inhibition, Fin regeneration	1	Tissue	Apr 21, 2020	Jul 10, 2020	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
1758	Impaired, Spermatogenesis Short Name Impaired, Spermatogenesis	1	Organ	Apr 16, 2020	Apr 10, 2024	5 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory 521: Essential element imbalance leads to reproductive failure via oxidative stress 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 595: Emerging OPFRS reproductive outcome pathway
1757	Reduce, Sperm count Short Name Reduce, Sperm count	0	Individual	Apr 6, 2020	Apr 6, 2020	3 AOPs 322: Alkylation of DNA leading to reduced sperm count 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility 616: organic UV filter and its Photoproducts reproductive toxicity pathways
1756	Decreased, plasma 11-ketotestosterone level Short Name Decreased, 11KT	1	Tissue	Mar 23, 2020	May 24, 2022	3 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
1755	beta-catenin activation Short Name beta-catenin activation	1	Cellular	Mar 23, 2020	Nov 25, 2022	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
1754	Increase, porcupine-induced Wnt secretion and Wnt signaling activation Short Name	1	Cellular	Mar 23, 2020	Jun 4, 2025	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer