AOP-Wiki

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All KERs

Showing 1701 to 1725 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1247	1182: Increase, Cell Proliferation (Epithelial Cells)	1192: Increased, Ductal Hyperplasia	Nov 29, 2016	Dec 3, 2016	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1907	1182: Increase, Cell Proliferation (Epithelial Cells)	185: Increase, Mutations	May 8, 2019	May 8, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
890	870: Increase, Cell Proliferation	376: Increased, Induced Mutations in Critical Genes	Nov 29, 2016	Dec 3, 2016	None
893	870: Increase, Cell Proliferation	876: Increase, Mutations in Critical Genes	Nov 29, 2016	Dec 3, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
895	870: Increase, Cell Proliferation	872: Increase, Site of Contact Nasal Tumors	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
1967	870: Increase, Cell Proliferation	1670: Lung cancer	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 451: Interaction with lung resident cell membrane components leads to lung cancer
1980	870: Increase, Cell Proliferation	1556: Increase, lung cancer	Aug 29, 2019	Jan 10, 2023	1 AOP 272: Deposition of energy leading to lung cancer
2419	870: Increase, Cell Proliferation	1090: Increased, mesotheliomas	Jul 6, 2021	Jul 6, 2021	1 AOP 409: Frustrated phagocytosis leads to malignant mesothelioma
2819	870: Increase, Cell Proliferation	2083: Cataracts	Dec 18, 2022	Mar 8, 2024	1 AOP 478: Deposition of energy leading to occurrence of cataracts
3750	870: Increase, Cell Proliferation	1395: Liver Cancer	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1746	1527: Increase, Cell membrane depolarization	1526: Increase, Opening of voltage-dependent calcium channel	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
2708	1527: Increase, Cell membrane depolarization	389: Increased, Intracellular Calcium overload	Jul 25, 2022	Jul 25, 2022	None
2788	1527: Increase, Cell membrane depolarization	55: Cell injury/death	Oct 19, 2022	Oct 19, 2022	1 AOP 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
3039	1527: Increase, Cell membrane depolarization	2187: Opening VGCCs	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
67	55: Cell injury/death	134: Increase, Kupffer cell activation	Nov 29, 2016	Nov 29, 2016	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
68	55: Cell injury/death	265: Increase, HSC activation	Nov 29, 2016	Apr 21, 2026	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 494: AhR activation leading to liver fibrosis
355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
364	55: Cell injury/death	352: N/A, Neurodegeneration	Nov 29, 2016	Sep 10, 2023	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
924	55: Cell injury/death	87: Release, Cytokine	Nov 29, 2016	Nov 9, 2018	None
1688	55: Cell injury/death	386: Neuronal network function, Decreased	Nov 9, 2017	Feb 5, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1718	55: Cell injury/death	1492: Tissue resident cell activation	Feb 1, 2018	Aug 2, 2018	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 38: Protein Alkylation leading to Liver Fibrosis
1776	55: Cell injury/death	1493: Increased pro-inflammatory mediators	Nov 12, 2018	Nov 12, 2018	1 AOP 144: Endocytic lysosomal uptake leading to liver fibrosis
1830	55: Cell injury/death	1548: Necrotic Tissue	Jan 7, 2019	Mar 7, 2019	2 AOPs 278: IKK complex inhibition leading to liver injury 273: Mitochondrial complex inhibition leading to liver injury
1831	55: Cell injury/death	1576: Activation, Tissue resident cells (Kuppfer cells)	Jan 7, 2019	Jan 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury

Key Event Relationships (KERs)

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