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Showing 1701 to 1725 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3198	55: Cell injury/death	177: Increase, Mitochondrial dysfunction	Apr 17, 2024	Apr 17, 2024	None
3244	55: Cell injury/death	2084: Increase, Cardiac remodelling	Jun 4, 2024	Jun 4, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
3245	55: Cell injury/death	1532: Decrease, Cardiac contractility	Jun 4, 2024	Jun 4, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2215	1825: Increase, Cell death	1521: Decrease, Growth	Dec 4, 2020	Dec 4, 2020	1 AOP 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
2467	1825: Increase, Cell death	1930: Altered, inner ear development	Aug 23, 2021	Aug 29, 2021	1 AOP 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
2489	1825: Increase, Cell death	1931: Disruption of the intestinal barrier	Oct 19, 2021	Oct 19, 2021	None
2706	1825: Increase, Cell death	896: Parkinsonian motor deficits	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2718	1825: Increase, Cell death	188: Neuroinflammation	Jul 25, 2022	Jul 25, 2022	None
2760	1825: Increase, Cell death	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2842	1825: Increase, Cell death	2089: Altered Bone Cell Homeostasis	Jan 25, 2023	Nov 6, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2863	1825: Increase, Cell death	758: Hippocampal Physiology, Altered	Apr 3, 2023	Apr 3, 2023	None
3504	1825: Increase, Cell death	2312: Increased, nasal lesions	Mar 5, 2025	Mar 19, 2025	1 AOP 368: Cytochrome oxidase inhibition leading to increased nasal lesions
3507	1825: Increase, Cell death	2316: Increased, pulmonary edema	Mar 12, 2025	Mar 24, 2025	1 AOP 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema
3508	1825: Increase, Cell death	2317: Loss of olfactory function	Mar 13, 2025	Mar 25, 2025	1 AOP 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
3765	1825: Increase, Cell death	1097: Occurrence, renal proximal tubular necrosis	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
2112	1779: Increase, Casp transcription (F3)	1780: Increase, Oocyte apoptosis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 340: DNA methyltransferase inhibition leading to transgenerational effects (1)
2116	1779: Increase, Casp transcription (F3)	1783: Increase, Ovarian somatic cell apoptosis (F3)	Apr 30, 2020	Apr 30, 2020	1 AOP 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2103	1774: Increase, Casp transcription	1775: Increase, Oocyte apoptosis	Apr 30, 2020	Apr 30, 2020	2 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 338: DNA methyltransferase inhibition leading to population decline (3)
2105	1774: Increase, Casp transcription	1776: Increase, Ovarian somatic cell apoptosis	Apr 30, 2020	Apr 30, 2020	1 AOP 337: DNA methyltransferase inhibition leading to population decline (2)
3175	2084: Increase, Cardiac remodelling	2215: Decrease LV function	Apr 3, 2024	Apr 3, 2024	1 AOP 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
60	50: Increase, Ca++ (intracellular)	178: Mitochondrial electron transport chain, disrupted	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
2845	2090: Bone Remodeling	2091: Bone Loss	Jan 25, 2023	Aug 9, 2024	1 AOP 482: Deposition of energy leading to occurrence of bone loss
2741	2048: Increase, Body volume of female adults	2050: Increase, developmental abnormalities	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2092	1769: Increase, Body fluid overload	350: Increase, Mortality	Apr 30, 2020	Apr 30, 2020	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
2236	401: Increase, Biliary excretion TH glucuronide	281: T4 in serum, Decreased	Dec 9, 2020	Dec 9, 2020	None

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