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Showing 2451 to 2475 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2824	1532: Decrease, Cardiac contractility	1535: Heart failure	Jan 5, 2023	Jan 5, 2023	3 AOPs 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
3176	1532: Decrease, Cardiac contractility	2215: Decrease LV function	Apr 3, 2024	Apr 3, 2024	2 AOPs 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
1756	1530: Decrease, Calcium currents	1531: Decrease, Calcium binding to Troponin C	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1760	1530: Decrease, Calcium currents	1536: Disruption, Intracellular calcium mobilization	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1757	1531: Decrease, Calcium binding to Troponin C	1532: Decrease, Cardiac contractility	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
2176	1808: Decrease, ATP synthase activity	1771: Decrease, ATP pool	Nov 2, 2020	Nov 2, 2020	None
2344	1808: Decrease, ATP synthase activity	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	None
1664	1472: Decrease, ATP production	1473: Decrease, Chlorophyll synthesis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
2341	1472: Decrease, ATP production	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
2547	1472: Decrease, ATP production	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3559	1472: Decrease, ATP production	360: Decrease, Population growth rate	Aug 5, 2025	Feb 27, 2026	None
3772	1472: Decrease, ATP production	1521: Decrease, Growth	Apr 10, 2026	Apr 10, 2026	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
961	914: Decreased ciliated cell apoptosis	919: Occurrence, Transdifferentiation of ciliated epithelial cells	Nov 29, 2016	Aug 25, 2021	None
2470	914: Decreased ciliated cell apoptosis	920: Goblet cell metaplasia	Aug 25, 2021	Aug 25, 2021	None
1937	1614: Decrease, AR activation	1615: Impaired inguinoscrotal phase	Jun 3, 2019	Jun 3, 2019	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
2124	1614: Decrease, AR activation	286: Altered, Transcription of genes by the AR	May 11, 2020	Mar 20, 2026	10 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring
2820	1614: Decrease, AR activation	1688: AGD, decreased	Dec 22, 2022	Feb 4, 2026	3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
2828	1614: Decrease, AR activation	2082: Hypospadias	Jan 11, 2023	Mar 20, 2026	3 AOPs 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
3348	1614: Decrease, AR activation	1786: nipple retention, increased	Sep 26, 2024	Mar 20, 2026	3 AOPs 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3451	1614: Decrease, AR activation	743: Decreased, Testosterone binding to androgen receptor (hypothalamus)	Dec 23, 2024	Dec 23, 2024	1 AOP 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
2096	1771: Decrease, ATP pool	350: Increase, Mortality	Apr 30, 2020	Apr 30, 2020	2 AOPs 328: Excessive reactive oxygen species production leading to mortality (2) 329: Excessive reactive oxygen species production leading to mortality (3)
2120	1771: Decrease, ATP pool	1775: Increase, Oocyte apoptosis	May 8, 2020	May 8, 2020	None
2121	1771: Decrease, ATP pool	1607: Increase, Necrosis	May 8, 2020	May 8, 2020	None
2179	1771: Decrease, ATP pool	1810: Decrease, ATPase activity	Nov 2, 2020	Nov 2, 2020	None
2204	1771: Decrease, ATP pool	1821: Decrease, Cell proliferation	Nov 12, 2020	Dec 7, 2020	6 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation

Key Event Relationships (KERs)

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