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All KERs

Showing 1976 to 2000 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2486	351: Increased Mortality	679: Decline, Population trajectory	Oct 8, 2021	Oct 8, 2021	None
1858	1602: Activation, Muscarinic Acetylcholine Receptors	1350: Increased, glutamate	Feb 13, 2019	Feb 13, 2019	None
1889	1602: Activation, Muscarinic Acetylcholine Receptors	1623: Occurrence, Focal Seizure	Apr 22, 2019	Sep 3, 2023	1 AOP 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
3402	1602: Activation, Muscarinic Acetylcholine Receptors	1098: Increased, blood potassium concentration	Nov 20, 2024	Nov 20, 2024	1 AOP 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
3431	1602: Activation, Muscarinic Acetylcholine Receptors	698: Altered, Action Potential	Nov 22, 2024	Nov 22, 2024	1 AOP 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
2430	1897: MyD88 activation	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Jul 8, 2021	Jul 8, 2021	1 AOP 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1584	1435: Increased NKA	1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea	Jun 23, 2017	Jun 23, 2017	None
1585	1435: Increased NKA	1225: Leukocyte infiltration	Jun 23, 2017	Jun 23, 2017	None
1773	1435: Increased NKA	1226: Respiratory irritability	Sep 24, 2018	Sep 24, 2018	1 AOP 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
3535	2324: Dysregulation of Treg/Th17 cell ratio	2325: Decreased number of LT CD8+ cells	May 16, 2025	May 16, 2025	None
3538	2324: Dysregulation of Treg/Th17 cell ratio	2326: CTL cytotoxicity	May 22, 2025	May 22, 2025	1 AOP 578: AhR activation leading to cancer progression via immunosuppression
1193	1147: increased or inappropriate, mantel display	1141: Decreased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
1219	1147: increased or inappropriate, mantel display	1143: Depletion, energy reserves	Nov 29, 2016	Dec 3, 2016	None
1220	1147: increased or inappropriate, mantel display	1167: induced, parturition	Nov 29, 2016	Dec 3, 2016	None
3471	2303: Plasma estradiol/progesterone ratio, increase	2251: Increased E2 availability	Jan 10, 2025	Jan 14, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
3473	2303: Plasma estradiol/progesterone ratio, increase	2306: Persistent vaginal cornification	Jan 13, 2025	Jan 14, 2025	1 AOP 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1954	1662: plasma homocysteine increases	1663: brain Homocysteine level increases	Jun 14, 2019	Jun 14, 2019	None
3781	1889: premature meiosis, male germ cells	1890: Germ cell loss, male	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
2902	2132: Increased cytokine expression	1633: Increase in inflammation	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1719	1493: Increased pro-inflammatory mediators	55: Cell injury/death	Feb 1, 2018	Feb 12, 2018	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1764	1493: Increased pro-inflammatory mediators	265: Increase, HSC activation	Aug 2, 2018	Aug 2, 2018	1 AOP 38: Protein Alkylation leading to Liver Fibrosis
1777	1493: Increased pro-inflammatory mediators	1494: Leukocyte recruitment/activation	Nov 12, 2018	Nov 12, 2018	3 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1902	1493: Increased pro-inflammatory mediators	1193: N/A, Breast Cancer	May 7, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1903	1493: Increased pro-inflammatory mediators	1632: Increase in RONS	May 7, 2019	May 9, 2019	2 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1908	1493: Increased pro-inflammatory mediators	1182: Increase, Cell Proliferation (Epithelial Cells)	May 10, 2019	May 10, 2019	2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer

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