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All Key Events

Showing 926 to 950 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1450	decreased dopamine Short Name decreased dopamine	0	Molecular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1449	increased adipogenesis Short Name increased adipogenesis	0	Tissue	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1448	activation of CCAAT/enhancer-binding protein alpha Short Name activation of CEBPA	0	Molecular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1447	obesity Short Name obesity	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1446	Decrease, Coupling of oxidative phosphorylation Short Name Decrease, Coupling of OXPHOS	3	Cellular	Jun 29, 2017	Nov 7, 2025	17 AOPs 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
1445	Increase, Lipid peroxidation Short Name Increase, LPO	1	Molecular	Jun 29, 2017	Oct 8, 2024	8 AOPs 329: Excessive reactive oxygen species production leading to mortality (3) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 332: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell growth 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 333: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and reduced cell proliferation 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
1444	Increase, Follicular atresia Short Name Increase, Follicular atresia	0	Organ	Jun 29, 2017	Nov 25, 2020	2 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia
1443	Atherosclerosis Short Name Atherosclerosis	1	Individual	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1442	Foam cell formation Short Name Foam cell formation	0	Organ	Jun 29, 2017	Jun 29, 2017	462: Activation of reactive oxygen species leading the atherosclerosis
1441	Increased systemic total cholesterol pool Short Name Systemic cholesterol increased	0	Organ	Jun 29, 2017	Jun 29, 2017	None
1440	Formation of HDL-SAA Short Name HDL-SAA formation	0	Cellular	Jun 29, 2017	Jun 29, 2017	None
1439	Systemic acute phase response Short Name Systemic acute phase response	1	Organ	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1438	Transcription of genes encoding acute phase proteins, Increased Short Name	1	Organ	Jun 29, 2017	Dec 18, 2023	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
1437	Sensing of the stressor by pulmonary cells Short Name Sensing of the stressor	0	Molecular	Jun 29, 2017	Jun 29, 2017	None
1436	neurogenic inflammation of sensory nerves Short Name neurogenic inflammation	0	Cellular	Jun 27, 2017	Jun 27, 2017	None
1435	Increased neurokinin A (NKA) by neuronal cells Short Name Increased NKA	1	Cellular	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1434	Irritation of nasal mucosa inducing sneeze reflex Short Name Irritation induced sneezing	1	Tissue	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1433	Increased CGRP, neuronal release of CGRP Short Name Increased CGRP	1	Cellular	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1432	Anti-depressant Activity Short Name Anti-depressant Activity	0	Individual	Jun 23, 2017	Jun 23, 2017	2 AOPs 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1431	Serotonin 1A Receptor Agonism Short Name Serotonin 1A Receptor Agonism	0	Molecular	Jun 23, 2017	Jun 23, 2017	2 AOPs 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1430	Inhibition of neurotransmitter vesicle release Short Name Inhibition of neurotransmitter release	0	Cellular	Jun 23, 2017	Jun 27, 2023	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1429	Inhibition of N-type Ca ion channels Short Name Inhibition of Ca Channels	0	Cellular	Jun 23, 2017	Jun 23, 2017	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1428	Analgesia Short Name Analgesia	0	Individual	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
1427	Opening of G protein gated inward rectifying K channels Short Name Opening of GIRK channels	0	Cellular	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
1426	Release of G Proteins Short Name Release of G Proteins	0	Cellular	Jun 8, 2017	Jun 8, 2017	4 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition