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All Key Events

Showing 1451 to 1475 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

851	Decrease of GABAergic interneurons Short Name GABAergic interneurons, Decreased	1	Cellular	Nov 29, 2016	Apr 4, 2019	2 AOPs 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
850	Induction, CYP1A2/CYP1A5 Short Name Induction, CYP1A2/CYP1A5	2	Molecular	Nov 29, 2016	May 30, 2018	2 AOPs 131: Aryl hydrocarbon receptor activation leading to uroporphyria 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
849	Inhibition, Antgonism of NE receptor Short Name Inhibition, Antgonism of NE receptor	1	Molecular	Nov 29, 2016	Dec 3, 2016	126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
848	Decreased, Binding of NE to NE receptors on GnRH neurons Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
846	Accumulation, Highly carboxylated porphyrins Short Name	1	Organ	Nov 29, 2016	May 7, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
845	Inhibition, UROD Short Name Inhibition, UROD	1	Molecular	Nov 29, 2016	May 30, 2018	131: Aryl hydrocarbon receptor activation leading to uroporphyria
844	Oxidation, Uroporphyrinogen Short Name Oxidation, Uroporphyrinogen	1	Cellular	Nov 29, 2016	Sep 16, 2017	131: Aryl hydrocarbon receptor activation leading to uroporphyria
840	Formation, Liver fibrosis Short Name Formation, Liver fibrosis	1	Tissue	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
839	Formation, Mallory body Short Name Formation, Mallory body	1	Cellular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
838	Induction, Microvesicular fat Short Name Induction, Microvesicular fat	1	Tissue	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
837	Occurrence, Cytoplasmic vacuolization (kupffer cell) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
836	Occurrence, Cytoplasmic vacuolization (Bile duct cell) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
835	Occurrence, Ballooning degeneration (hepatocyte) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
833	Occurrence, Cytoplasmic vacuolization (hepatocyte) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
831	Disturbance, Lysosomal function Short Name Disturbance, Lysosomal function	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
829	Damage, Lipid bilayer Short Name Damage, Lipid bilayer	1	Cellular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
828	Inhibition, Phospholipase A Short Name Inhibition, Phospholipase A	1	Molecular	Nov 29, 2016	Dec 3, 2016	130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
827	sensitisation, skin Short Name sensitisation, skin	0	Organ	Nov 29, 2016	Nov 29, 2016	40: Covalent Protein binding leading to Skin Sensitisation
826	Activation, Keratinocytes Short Name Activation, Keratinocytes	2	Cellular	Nov 29, 2016	Sep 16, 2017	40: Covalent Protein binding leading to Skin Sensitisation
825	Decreased, Renal ability to dilute urine Short Name	1	Organ	Nov 29, 2016	Dec 3, 2016	128: Kidney dysfunction by decreased thyroid hormone
824	Occurrence, Cytoplasmic vacuolization (podocyte) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
823	Occurrence, Cystic dilatation (renal tubule) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
821	Decreased, Sodium reabsorption Short Name Decreased, Sodium reabsorption	1	Organ	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
820	Decreased, Renal plasma flow Short Name Decreased, Renal plasma flow	1	Tissue	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone
819	Decreased, Glomerular filtration Short Name Decreased, Glomerular filtration	1	Tissue	Nov 29, 2016	Sep 16, 2017	128: Kidney dysfunction by decreased thyroid hormone