AOP-Wiki

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All Key Events

Showing 1876 to 1900 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

116	Activation, FAS Short Name Activation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	34: LXR activation leading to hepatic steatosis
115	Increase, Fatty acid influx Short Name Increase, FA influx	1	Cellular	Nov 29, 2016	Feb 11, 2026	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
112	Antagonism, Estrogen receptor Short Name Antagonism, Estrogen receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 30: Estrogen receptor antagonism leading to reproductive dysfunction 443: DNA damage and mutations leading to Metastatic Breast Cancer 522: Estrogen antagonism leading to increased risk of autism-like behavior 595: Emerging OPFRS reproductive outcome pathway
111	Agonism, Estrogen receptor Short Name Agonism, Estrogen receptor	2	Molecular	Nov 29, 2016	Sep 11, 2025	8 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males 53: ER agonism leading to reduced survival due to renal failure 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 200: Estrogen receptor activation leading to breast cancer 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
110	Impairment, Endothelial network Short Name Impairment, Endothelial network	1	Cellular	Nov 29, 2016	Jan 18, 2022	2 AOPs 43: Disruption of VEGFR Signaling Leading to Developmental Defects 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
106	Reduction, Eggshell thickness Short Name Reduction, Eggshell thickness	1	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
105	Inhibition, Mitochondrial Electron Transport Chain Complexes Short Name	0	Molecular	Nov 29, 2016	Mar 22, 2023	4 AOPs 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
103	Increase, Ecdysone receptor hyperactivation Short Name Increase, EcR hyperactivation	1	Molecular	Nov 29, 2016	Sep 29, 2025	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
97	Alkylation, DNA Short Name Alkylation, DNA	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 141: Alkylation of DNA leading to cancer 2 322: Alkylation of DNA leading to reduced sperm count
89	Synthesis, De Novo Fatty Acid (FA) Short Name Synthesis, De Novo Fatty Acid (FA)	1	Cellular	Nov 29, 2016	Mar 29, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis
87	Release, Cytokine Short Name Release, Cytokine	1	Cellular	Nov 29, 2016	Sep 16, 2017	5 AOPs 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) 303: Frustrated phagocytosis-induced lung cancer 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 412: Endothelial cell dysfunction leading to thromboinflammation 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
84	Up Regulation, CYP1B1 Short Name Up Regulation, CYP1B1	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
80	Up Regulation, CYP1A1 Short Name Up Regulation, CYP1A1	1	Molecular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
79	Inhibition, Cyclooxygenase activity Short Name Inhibition, Cyclooxygenase activity	2	Molecular	Nov 29, 2016	Sep 16, 2017	6 AOPs 28: Cyclooxygenase inhibition leading reproductive failure 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
78	Reduction, Cumulative fecundity and spawning Short Name	1	Individual	Nov 29, 2016	Mar 20, 2017	17 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
77	Production, Critical Metabolites (CGA 330050 and CGA 265307) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
75	N/A, Covalent binding to protein, possibly lysine residue Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	None
68	Increase, Collagen accumulation Short Name Increase, Collagen accumulation	1	Tissue	Nov 29, 2016	Feb 11, 2026	12 AOPs 38: Protein Alkylation leading to Liver Fibrosis 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
66	Activation, ChREBP Short Name Activation, ChREBP	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
64	Reduction, Ionotropic GABA receptor chloride channel conductance Short Name	1	Cellular	Nov 29, 2016	Feb 6, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
60	Induction, Chitin degradation and resorption Short Name	0		Nov 29, 2016	Nov 29, 2016	None
59	Inhibition of Apoptosis in Altered Hepatic Foci, Changes in Cellular Growth Homeostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None
57	Proliferation, Cell proliferation in the absence of cytotoxicity Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
55	Increase, Cell injury/death Short Name Cell injury/death	1	Cellular	Nov 29, 2016	May 27, 2024	28 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 38: Protein Alkylation leading to Liver Fibrosis 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 144: Endocytic lysosomal uptake leading to liver fibrosis 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 278: IKK complex inhibition leading to liver injury 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 273: Mitochondrial complex inhibition leading to liver injury 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 494: AhR activation leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
54	Up Regulation, CD36 Short Name Up Regulation, CD36	1	Molecular	Nov 29, 2016	Mar 26, 2024	5 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis