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All Key Events

Showing 1276 to 1300 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1086	persistent, cytotoxicity (pleura or peritoneum) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1085	Increased, hyperplasia (mammary gland) Short Name Increased, hyperplasia (mammary gland)	1	Tissue	Nov 29, 2016	Sep 16, 2017	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1084	Increased, prolactin secretion Short Name Increased, prolactin secretion	1	Tissue	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1083	Decreased, Dopaminergic activity Short Name Decreased, Dopaminergic activity	1	Cellular	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1082	Increased, adenomas (pituitary) Short Name Increased, adenomas (pituitary)	1	Tissue	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1081	Increased, lactotroph hyperplasia and hypertrophy Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1080	Increased, latency period Short Name Increased, latency period	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1079	Increased, Adenomas/carcinomas (mammary) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1078	Hyperplasia, Mammary gland Short Name Hyperplasia, Mammary gland	1	Tissue	Nov 29, 2016	Sep 16, 2017	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1077	Increased, prolactin exposure Short Name Increased, prolactin exposure	1	Tissue	Nov 29, 2016	Dec 3, 2016	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1076	Increased, circulating estrogen levels Short Name Increased, circulating estrogen levels	1	Organ	Nov 29, 2016	Dec 3, 2016	4 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
1075	prolonged, estrus cycle Short Name prolonged, estrus cycle	2	Individual	Nov 29, 2016	Oct 3, 2025	4 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
1074	interruption, Ovulation Short Name interruption, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1073	anovulation, Short Name anovulation,	0		Nov 29, 2016	Nov 29, 2016	None
1072	Decreased, LH Surge from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1071	Decreased, GnRH pulsatility/release in hypothalamus Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1070	Increased, adenosquamous carcinomas of endometrium Short Name	2	Tissue	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1069	Increased, Hyperplasia (glandular epithelial cells of endometrium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1068	Endometrial squamous metaplasia, Increase Short Name	2	Cellular	Nov 29, 2016	Sep 18, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1067	Proliferation/Clonal Expansion, aberrant basal-type cells Short Name	1	Cellular	Nov 29, 2016	Aug 21, 2025	None
1066	Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium Short Name	1	Cellular	Nov 29, 2016	Sep 12, 2025	167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
1065	Activation, estrogen receptor alpha Short Name Activation, ERα	2	Molecular	Nov 29, 2016	Jan 28, 2026	11 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
1063	Increased, Pancreatic acinar tumors Short Name Increased, Pancreatic acinar tumors	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1062	Increased, Cellular proliferation / hyperplasia of acinar cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1061	prolonged, elevation of serun CCK Short Name prolonged, elevation of serun CCK	1	Tissue	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse