Key Event Relationships (KERs)

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Showing 2126 to 2150 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
346 376: Increased, Induced Mutations in Critical Genes 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 30, 2016
351 376: Increased, Induced Mutations in Critical Genes 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None
549 376: Increased, Induced Mutations in Critical Genes 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
891 376: Increased, Induced Mutations in Critical Genes 872: Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 3, 2016 None
762 726: Increased, Induction of pyruvate dehydrogenase (PDH) 769: Increase, Oxidative metabolism Nov 29, 2016 Dec 3, 2016
1063 1020: Increased, induction of UDPGT's in liver 1021: Increased, T4/T3 catabolism Nov 29, 2016 Dec 3, 2016 None
1127 1087: Increased, inflammation 1032: Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
1048 1012: Increased, Inhibitory postsynaptic potential 1013: Inhibition, Motor neuron activity Nov 29, 2016 Dec 3, 2016 None
1054 1012: Increased, Inhibitory postsynaptic potential 1014: Induction, Somatic muscle paralysis Nov 29, 2016 Dec 3, 2016
1058 1012: Increased, Inhibitory postsynaptic potential 1019: Induction, pharyngeal muscle paralysis Nov 29, 2016 Dec 3, 2016
547 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts 376: Increased, Induced Mutations in Critical Genes Nov 29, 2016 Nov 29, 2016
362 389: Increased, Intracellular Calcium overload 177: Increase, Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016
892 389: Increased, Intracellular Calcium overload 618: Decreased, Neuronal network function in adult brain Nov 29, 2016 Dec 3, 2016 None
1860 389: Increased, Intracellular Calcium overload 613: Occurrence, Epileptic seizure Feb 13, 2019 Feb 13, 2019 None
1862 389: Increased, Intracellular Calcium overload 55: Cell injury/death Feb 19, 2019 Sep 3, 2023
2140 389: Increased, Intracellular Calcium overload 1788: Status epilepticus May 21, 2020 May 21, 2020 None
2704 389: Increased, Intracellular Calcium overload 2038: Activation, calpain Jul 25, 2022 Jul 25, 2022
2709 389: Increased, Intracellular Calcium overload 1477: OXPHOS, decreased Jul 25, 2022 Jul 25, 2022 None
2710 389: Increased, Intracellular Calcium overload 2017: Endoplasmic reticulum stress Jul 25, 2022 Jul 25, 2022
3042 389: Increased, Intracellular Calcium overload 1816: Mitochondrial dysfunction EMPTY Sep 14, 2023 Sep 14, 2023 None
3091 389: Increased, Intracellular Calcium overload 2078: Loss of drebrin Oct 18, 2023 Apr 4, 2025
3248 389: Increased, Intracellular Calcium overload 1392: Increase, Oxidative Stress Jun 19, 2024 Jun 19, 2024
3256 389: Increased, Intracellular Calcium overload 2151: Disruption, neurotransmitter release Jun 19, 2024 Jun 19, 2024
3426 389: Increased, Intracellular Calcium overload 1532: Decrease, Cardiac contractility Nov 21, 2024 Nov 21, 2024
1465 1322: Increased, intracellular chloride (Cl-) 1356: Inactive, membrane depolarization Apr 14, 2017 Apr 14, 2017